• 中国中文核心期刊
  • 中国科学引文数据库核心期刊
  • 中国科技核心期刊
  • 中国高校百佳科技期刊
高级检索

碳纳米材料在肿瘤药物递送系统的研究进展

李浩贤, 林华庆, 陈靖文, 王利媛

李浩贤, 林华庆, 陈靖文, 王利媛. 碳纳米材料在肿瘤药物递送系统的研究进展[J]. 中国药科大学学报, 2019, 50(1): 100-106. DOI: 10.11665/j.issn.1000-5048.20190114
引用本文: 李浩贤, 林华庆, 陈靖文, 王利媛. 碳纳米材料在肿瘤药物递送系统的研究进展[J]. 中国药科大学学报, 2019, 50(1): 100-106. DOI: 10.11665/j.issn.1000-5048.20190114
shu
LI Haoxian, LIN Huaqing, CHEN Jingwen, WANG Liyuan. Research progress of carbon nanomaterials in cancer drug delivery[J]. Journal of China Pharmaceutical University, 2019, 50(1): 100-106. DOI: 10.11665/j.issn.1000-5048.20190114
Citation: LI Haoxian, LIN Huaqing, CHEN Jingwen, WANG Liyuan. Research progress of carbon nanomaterials in cancer drug delivery[J]. Journal of China Pharmaceutical University, 2019, 50(1): 100-106. DOI: 10.11665/j.issn.1000-5048.20190114
shu

碳纳米材料在肿瘤药物递送系统的研究进展

  • 广东药科大学药学院广东省药物新剂型重点实验室

基金项目: 广州市重点实验室专项基金资助项目(No.2014SY000005)；广东省科技计划资助项目(No.2013B08080007)

Research progress of carbon nanomaterials in cancer drug delivery

摘要

    摘要
  • 摘要: 碳纳米材料是目前肿瘤药物递送系统研究的热点之一，与传统的肿瘤治疗载药系统相比，具有比表面积大、独特的光学性质等优点，经过修饰后可用作药物载体，具有载药量高、生物相容性好、肿瘤靶向性、作用时间持久等特点，因此具有很大的潜力与开发空间。本文按维度量子性顺序分别介绍了量子点、碳纳米管、氧化石墨烯、介孔碳纳米球4种碳纳米材料的性质与功能的特点及其近几年来在肿瘤治疗领域中的研究进展，并讨论了碳纳米材料目前的研究重点与存在的问题，以期为碳纳米材料安全有效地应用于肿瘤治疗的研究提供理论参考。
    Abstract: Carbon nanomaterials are one of the hotspots in the research of drug delivery systems for cancer. Compared with the traditional drug delivery systems for cancer treatment, carbon nanomaterials can be used as drug carriers after modification based on their advantages of large specific surface area and unique optical properties. They have the characteristics of high drug loading, good biocompatibility, tumor targeting and lasting action time, indicating great potential and development space. In this paper, the properties and functions of quantum dots, carbon nanotubes, graphene oxide and mesoporous carbon nanospheres are introduced in the order of dimensional quantum properties. The current research focus and existing problems of carbon nanomaterials are discussed in order to provide a reference for the safe and effective application of carbon nanomaterials in tumor therapy.
    • HTML全文
    • 参考文献(59)
  • [1] Ha XQ,Zhang SD,Yang ZH,et al.New technology in tumor biotherapy - targeted gene therapy[J].Med Pharm J Chin PLA(解放军医药杂志),2014,26(7):24-27.
    [2] Zhang L,Liu XY,Shen JJ,et al.Application of nanoparticles with targeting,triggered release in anti-cancer drug delivery[J].Prog Chem(化学进展),2013,25(8):1375-1382.
    [3] Zhao XB,Tian K,Zhou TT,et al.PEGylated multi-walled carbon nanotubes as versatile vector for tumor-specific intracellular triggered release with enhanced anti-cancer efficiency:optimization of length and PEGylation degree[J].Colloids Surf B,2018,168:43-49.
    [4] Kim H,Beack S,Han S,et al.Multifunctional photonic nanomaterials for diagnostic,therapeutic,and theranostic applications[J].Adv Mater,2018,30(10):1701460.
    [5] Cheng QY,Zhou D,Han BH.Supramolecular surface modification of carbon nanomaterials and its application[J].Chem J Chin Univ(高等学校化学学报),2011,32(9):2062-2070.
    [6] Song K,Pan H,Han JY,et al.Nano drug delivery system based strategies to target tumor microenvironment[J].J China Pharm Univ(中国药科大学学报),2018,49(4):392-400.
    [7] Peng ZZ,Ding L,Zhou JH,et al.Electrochemical performance of graphene/carbon quantum dots composites[J].J Wuhan Univ Sci Technol(武汉科技大学学报),2018,41(1):52-57.
    [8] Shi ZP,Shen SG,Yue ZL,et al.Progress in research of carrier systems for targeting and controlled release of anticancer drug[J].Chin J New Drugs(中国新药杂志),2017,26(4):410-419.
    [9] Wang CL,Ma D,Bao XH.Carbon nanomaterials and their heterogeneous catalytic application[J].Prog Chem(化学进展),2009,21(9):1705-1721.
    [10] Li CY,Meng Y,Wang SS,et al.Mesoporous carbon nanospheres featured fluorescent aptasensor for multiple diagnosis of cancer in vitro and in vivo[J].ACS Nano,2015,9(12):12096-12103.
    [11] Baker SN,Baker GA.Luminescent carbon nanodots:emergent nanolights[J].Angew Chem Int Ed,2010,49(38):6726-6744.
    [12] Shen JH,Zhu YH,Yang XL,et al.Graphene quantum dots:emergent nanolights for bioimaging,sensors,catalysis and photovoltaic devices[J].Chem Commun,2012,43(29):3686-3699.
    [13] Namdari P,Negahdari B,Eatemadi A.Synthesis,properties and biomedical applications of carbon-based quantum dots:an updated review[J].Biomed Pharmacother,2017,87:209-222.
    [14] Wang H.Research on synthesis and photoluminescence property of functionalized grapheme quantum dots(石墨烯量子点的功能化及生物荧光性能研究)[D].Taiyuan:Taiyuan University of Technology,2016.
    [15] Jha S,Mathur P,Ramteke S,et al.Pharmaceutical potential of quantum dots[J].Artif Cells Nanomed Biotechnol,2018,46(Sup 1):1-9.
    [16] Wang YF,Hu AG.Carbon quantum dots:synthesis,properties and applications[J].J Mater Chem C,2014,2(34):6921-6939.
    [17] Jiao J,Liu C,Li X,et al.Fluorescent carbon dot modified mesoporous silica nanocarriers for redox-responsive controlled drug delivery and bioimaging[J].J Colloid Interface Sci,2016,483:343-352.
    [18] Lim SY,Shen W,Gao Z.Carbon quantum dots and their applications[J].Chem Soc Rev,2015,44(1):362-381.
    [19] Gong XJ,Zhang QY,Gao YF,et al.Phosphorus and nitrogen dual-doped hollow carbon dot as a nanocarrier for doxorubicin delivery and biological imaging[J].ACS Appl Mater Inter,2016,8(18):11288-11297.
    [20] Feng T,Ai X,Ong H,et al.Dual-responsive carbon dots for tumor extracellular microenvironment triggered targeting and enhanced anticancer drug delivery[J].ACS Appl Mater Inter,2016,8(29):18732-18740.
    [21] Yan X,Li B,Li LS.Colloidal graphene quantum dots with well-defined structures[J].Acc Chem Res, 2013,46(10):2254-2262.
    [22] Li LL,Wu GH,Yang GH,et al.Focusing on luminescent graphene quantum dots:current status and future perspectives[J].Nanoscale,2013,5(10):4015-4039.
    [23] Wang C,Wu CY,Zhou XJ,et al.Enhancing cell nucleus accumulation and DNA cleavage activity of anti-cancer drug via graphene quantum dots[J].Sci Rep,2013,3(6154):2852.
    [24] Wo FJ,Xu RJ,Shao YX,et al.A multimodal system with synergistic effects of magneto-mechanical,photothermal,photodynamic and chemo therapies of cancer in graphene-quantum dot-coated hollow magnetic nanospheres[J].Theranostics,2016,6(4):485-500.
    [25] Khodadadei F,Safarian S,Ghanbari N.Methotrexate-loaded nitrogen-doped graphene quantum dots nanocarriers as an efficient anticancer drug delivery system[J].Mater Sci Eng C Mater Biol Appl,2017,79:280-285.
    [26] Chong Y,Ma YF,Shen H,et al.The in vitro and in vivo toxicity of graphene quantum dots[J].Biomaterials,2014,35(19):5041-5048.
    [27] Ates M,Eker AA,Eker B.Carbon nanotube-based nanocomposites and their applications[J].J Adhes Sci Technol,2017,31(18):1-21.
    [28] Guo Q, Shen XT, Li YY, et al. Carbon nanotubes-based drug delivery to cancer and brain[J].J Huazhong Univ Sci Technol(华中理工大学学报),2017,37(5):635-641.
    [29] Comparetti EJ,Pedrosa VA,Kaneno R.Carbon nanotubes as a tool for fighting cancer[J].Bioconjugate Chem,2017,29(3):709-718.
    [30] Lee Y,Geckeler KE.Carbon nanotubes in the biological interphase:the relevance of noncovalence[J].Adv Mater,2010,22(36):4076-4083.
    [31] Wang PT.Research progress of antitumor drug delivery system based on carbon nanotubes[J].J Logist Univ PAPF(武警后勤学院学报),2018,27(3):260-263.
    [32] Kam NWS,Dai H.Single walled carbon nanotubes for transport and delivery of biological cargos[J].Phys Status Solidi B,2006,243(13):3561-3566.
    [33] Pantarotto D,Briand JP,Prato M,et al.Translocation of bioactive peptides across cell membranes by carbon nanotubes[J].Chem Commun,2004,10(1):16-17.
    [34] Yu BD,Tan L,Zheng RH,et al.Targeted delivery and controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon nanotubes[J].Mater Sci Eng C Mater Biol Appl,2016,68:579-584.
    [35] Meng A,Yang T,Wang PT,et al.Preparation and performance of LID-MWCNT based sustained release targeted drug delivery system[J].Tianjin Med J(天津医药),2015,43(08):852-855,961.
    [36] Lv GJ,Tang Y,Shen YF,et al.Pulmonary toxicity of single-wall carbon nanotubes and its oxidative stress mechanism[J].Acad J Second Military Med Univ(第二军医大学学报),2016,37(7):815-820.
    [37] Novoselov KS,Geim AK,Morozov SV,et al.Electric field effect in atomically thin carbon films[J].Science,2004,306(5696):666-669.
    [38] Thapa RK,Kim JH,Jeong JH,et al.Silver nanoparticle-embedded graphene oxide-methotrexate for targeted cancer treatment[J].Colloids Surf B Biointerfaces,2017,153:95-103.
    [39] Huang GJ,Chen ZG,Li MD,et al.Surface functional modification of graphene and graphene oxide[J].Acta Chim Sin(化学学报),2016,74(10):789-799.
    [40] Lin YW,Guo XF.Chemical modification of grapheme and its applications[J].Acta Chim Sin(化学学报),2014,72(3),277-288.
    [41] Guo Y,Li WX,Zheng MY,et al.Facile preparation of graphene dots functionalized Au nanoparticles and their application as peroxidase mimetics in glucose detection[J].Acta Chim Sin(化学学报),2014,72(6):713-719.
    [42] Zhang XY,Yang CY,Zhou JP,et al.Somatostatin receptor-mediated tumor-targeting nanocarriers based on octreotide-PEG conjugated nanographene oxide for combined chemo and photothermal therapy[J]. Small,2016,12(26):3578-3590.
    [43] Yang HH, Bremner DH, Tao L, et al. Carboxymethyl chitosan-mediated synthesis of hyaluronic acid-targeted graphene oxide for cancer drug delivery[J].Carbohydr Polym,2016,135:72-78.
    [44] Zheng TT,Gao Y,Deng XX,et al.Comparisons between graphene oxide and graphdiyne oxide in physicochemistry biology and cytotoxicity[J].ACS Appl Mater Inter,2018,10(39):32946-32954.
    [45] Liang GH,Li YL.Mesoporous carbon nanospheres:synthesis and application on drug delivery[J].Acta Laser Biology Sinica(激光生物学报),2017,26(5):398-406,418.
    [46] Wang H,Li XG,Ma ZQ,et al.Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy[J].Int J Nanomed,2016,11:1793-1806.
    [47] Li CY,Qian M,Wang SS,et al.Aptavalve-gated mesoporous carbon nanospheres image cellular mucin and provide on-demand targeted drug delivery[J].Theranostics,2017,7(13):3319-3325.
    [48] Zhao QF,Lin YZ,Han N,et al.Mesoporous carbon nanomaterials in drug delivery and biomedical application[J].Drug Deliv,2017,24(suppl 1):94-107.
    [49] Zheng J,Chen L,Zhang H,et al.Research progress in ordered mesoporous carbon nanomaterials:Synthesis and construction of drug delivery systems[J].Mater Rev(材料导报),2017,31(21):151-157.
    [50] Zhou LB,Jing Y,Liu YB,et al.Mesoporous carbon nanospheres as a multifunctional carrier for cancer theranostics[J].Theranostics,2018,8(3):663-675.
    [51] Zhao P,Wang LH,Sun CS,et al.Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study[J].Eur J Pharm Biopharm,2012,80(3):535-543.
    [52] Wang LZ,Yue LJ,Kang AF,et al.Effects on the dispersion and cytotoxicity of ordered mesporous carbon nanoparticles modifies with PVP or PEG[J].J Pharm Pract(药学实践杂志),2016,24(2):158-162.
    [53] Feng Y,Hu K,Chen YZ,et al.SiRNA delivery with PEGylated graphene oxide nanosheets for combined photothermal and genetherapy for pancreatic cancer[J].Theranostics,2017,7(5):1133-1148.
    [54] Mei XG.Examining the essence and safety of nano-carriers biotoxicity from a new perspective[N].Chin Pharm News(中国医药报),2015-04-07(004).
    [55] Yu B,Lian HY,Wang Y,et al.Research advance of nanomaterials in cancer treatment[J].Chin J Cell Biol(中国细胞生物学学报),2015,37(4):594-598.
    [56] Ho BN,Pfeffer C M,Singh A.Update on nanotechnology-based drug delivery systems in cancer treatment[J].Anticancer Res,2017,37(11):5975-5981.
    [57] Gao GY,Chen ML,Li MY,et al.Current status and prospect of translational medicine in nanotechnology[J].Acta Pharm Sin(药学学报),2015,50(8):919-924.
    [58] Tiet P,Berlin J.Exploiting homing abilities of cell carriers:Targeted delivery of nanoparticles for cancer therapy[J].Biochem Pharmacol,2017,145:18-26.
    [59] Tonigold M,Simon J,Estupiñán D,et al.Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona[J].Nat Nanotechnol,2018,13:862-869.
    • 相关文章
    • 施引文献
    • 资源附件(0)
计量
  • 文章访问数: 
  • HTML全文浏览量:  0
  • PDF下载量: 
  • 被引次数: 0
出版历程
  • 刊出日期:  2019-02-24

目录

摘要
HTML全文
    参考文献(59)
    相关文章
    施引文献
    资源附件(0)

    /

    返回文章
    返回

    版权所有：《中国药科大学学报》编辑部苏ICP备05007142号

    地址：江苏省南京市鼓楼区童家巷24号（210009）电话: 025-83271566E-mail: xuebao@cpu.edu.cn

    本系统由 北京仁和汇智信息技术有限公司 开发  百度统计

    访问量：365358

    x 关闭 永久关闭