［18F］F-DOPA合成方法的研究进展
Research progress of synthetic methods of ［18F］F-DOPA
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摘要: 6-［18F］氟-3，4-二羟基-L-苯丙氨酸(［18F］F-DOPA)作为帕金森病的诊断试剂已应用30多年。目前应用的亲电合成方法存在着放化产率(RCY)低、比活度(SA)低等缺点，而近年来亲核取代合成［18F］F-DOPA的方法以无载体的［18F］F-作为亲核进攻试剂，可以克服以上缺点。本文综述了近年来报道的［18F］F-DOPA亲核取代合成的新方法。Abstract: ［18F］6-fluoro-3, 4-dihydroxy-L-phenylalanine(［18F］F-DOPA)has been used as a radiotracer for Parkinson′s disease over 30 years. The previously reported electrophilic synthesis method has low radiochemical yield(RCY), low specific activity(SA)and other defects. Recent reported nucleophilic synthesis of ［18F］F-DOPA could overcome the disadvantages. In this paper, the nucleophilic synthetic methods for ［18F］F-DOPA are reviewed.
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