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近红外二区荧光/光声双模态成像脂质体的制备与表征

Preparation and characterization of the second near-infrared window fluorescent/photoacoustic imaging liposomes

  • 摘要: 近红外二区(NIR-II)荧光染料IR-1061水溶性差、量子产率低,限制其在生物医学方面的应用。本研究将脂质体作为载体材料,增加其水溶性,并且将近红外一区(NIR-I)荧光染料IR-780同时负载于脂质体,以增强IR-1061在NIR-II的荧光强度。结果表明,980 nm激光照射下,脂质体表现出显著增强的特征荧光。此外,对脂质体粒径、外观、光热转换效率、光声性能以及细胞毒性进行考察。结果显示,本研究所制备的复合物脂质体可作为NIR-II荧光/光声双模态成像体系,具有用于诊断和引导肿瘤光热治疗的潜力。

     

    Abstract: The second near-infrared window(NIR-II)fluorescent dye IR-1061 has the disadvantage of poorwater solubility and low quantum yield, which limits its application in biomedicine. We used liposomes as the carrier to increase their water solubility, and co-loaded a near-infrared region(NIR-I)fluorescent dye IR-780 into liposomes to enhance the fluorescence intensity of IR-1061 in NIR-II. Results showed that the liposomes exhibited significantly enhanced characteristic fluorescence under 980 nm laser irradiation. In addition, particle size, appearance, photothermal conversion efficiency, photoacoustic performance and cytotoxicity of liposomes were examined. This study showed that these combined liposomes exhibited potential as a NIR-II fluorescence/photoacoustic bimodal imaging system for the diagnosis and guidance of tumor photothermal therapy.

     

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