Abstract:
Chemical investigation of the roots of
Uvaria grandiflora by repeated column chromatography(CC)over silica gel, ODS, Sephadex LH-20, and HPLC resulted in the isolation of twelve compounds. Their structures were identified as: epicatechin-(4
β→1′, 2→
O→2′)-phloroglucinol(
1 ), proanthocyanidin A-1(
2 ), proanthocyanidin A-2(
3 ), epicatechin(
4 ), phlorizin(
5 ), eriodictyol(
6 ),
erythro-guaiacylglycerol-8-
O-4′-(coniferyl alcohol)ether(
7 ),
threo-guaiacylglycerol-8-
O-4′-(coniferyl alcohol)ether(
8 ),
erythro-guaiacylglycerol-8-
O-4′-(sinapyl alcohol)ether(
9 ),
threo-syringylglycerol-8-
O-4′-(sinapyl alcohol)ether(
10 ), burselignan(
11 )and icariol A
2(
12 ). Compounds
1 to
12 were all isolated from this plant for the first time, and compound
1 was a new natural product.