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环状RNA与2型糖尿病关系及其临床应用

穆金铭, 刘悦, 张方方, 金亮

穆金铭, 刘悦, 张方方, 金亮. 环状RNA与2型糖尿病关系及其临床应用[J]. 中国药科大学学报, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316
引用本文: 穆金铭, 刘悦, 张方方, 金亮. 环状RNA与2型糖尿病关系及其临床应用[J]. 中国药科大学学报, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316
MU Jinming, LIU Yue, ZHANG Fangfang, JIN Liang. Relationship between circular RNA and type 2 diabetes and its clinical application[J]. Journal of China Pharmaceutical University, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316
Citation: MU Jinming, LIU Yue, ZHANG Fangfang, JIN Liang. Relationship between circular RNA and type 2 diabetes and its clinical application[J]. Journal of China Pharmaceutical University, 2020, 51(3): 374-378. DOI: 10.11665/j.issn.1000-5048.20200316

环状RNA与2型糖尿病关系及其临床应用

基金项目: 国家自然科学基金资助项目(No. 81570696)

Relationship between circular RNA and type 2 diabetes and its clinical application

Funds: This study was supported by the National Natural Science Foundation of China (No. 81570696)
  • 摘要: 环状RNA(circular RNA)是一类新发现的具有共价闭合环的非编码RNA,在2型糖尿病的发生发展中扮演着重要角色。本文从环状RNA调控胰岛β细胞功能及其调控心脏、肾脏等器官的代谢活动两方面,综述了环状RNA与2型糖尿病的关系,同时指出了环状RNA作为2型糖尿病及其并发症临床诊断标志物的可能性,以期为2型糖尿病的预防、诊断和治疗提供参考和研究方向。
    Abstract: Circular RNA (circRNA) is a novel type of non-coding RNA with covalently closed loops which plays an important role in the occurrence and development of type 2 diabetes. In this paper, the relationship between circRNA and type 2 diabetes in terms of the regulation of pancreatic β-cell function by circRNA and the metabolic activity of heart, kidney and other organs is reviewed, and the possibility of circRNA as a clinical diagnostic marker for type 2 diabetes and its complications is emphasized, hoping to provide reference and clues for the prevention, diagnosis and treatment of type 2 diabetes.
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出版历程
  • 收稿日期:  2019-12-29
  • 修回日期:  2020-05-12
  • 刊出日期:  2020-06-24

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