Abstract: Mental, emotional and other psychological factors have a direct effect on human health, and chronic stress produces neurotransmitters to suppress the body's immune system, after which homeostasis is destroyed, lead to cells losing their normal state and function and cancer cells being produced. As a result, cancer patients will experience chronic emotional stress and consequently, neurotransmitters will promote the occurrence and development of tumors. This review systematically summarizes the research progress of major neurotransmitters from two aspects: the normal physiological functions and the mechanism of action in the tumor occurrence and development,providing some insights into further exploration of new mechanism of neurotransmitters and the development of drugs that block the neurotransmitters.