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基质金属蛋白酶在疾病诊断中的应用及其检测方法

吴玉冰, 尹莉芳, 秦超

吴玉冰, 尹莉芳, 秦超. 基质金属蛋白酶在疾病诊断中的应用及其检测方法[J]. 中国药科大学学报, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514
引用本文: 吴玉冰, 尹莉芳, 秦超. 基质金属蛋白酶在疾病诊断中的应用及其检测方法[J]. 中国药科大学学报, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514
WU Yubing, YIN Lifang, QIN Chao. Clinical application and detection of matrix metalloproteinases in diagnosis[J]. Journal of China Pharmaceutical University, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514
Citation: WU Yubing, YIN Lifang, QIN Chao. Clinical application and detection of matrix metalloproteinases in diagnosis[J]. Journal of China Pharmaceutical University, 2020, 51(5): 614-621. DOI: 10.11665/j.issn.1000-5048.20200514

基质金属蛋白酶在疾病诊断中的应用及其检测方法

基金项目: 国家自然科学基金资助项目(No.81871477)

Clinical application and detection of matrix metalloproteinases in diagnosis

Funds: This study was supported by the National Natural Science Foundation of China (No. 81871477)
  • 摘要: 近年来,随着对基质金属蛋白酶与疾病关系的研究逐渐深入,越来越多的研究发现基质金属蛋白酶与多种疾病的严重程度、诊断和预后等密切相关。因此基质金属蛋白酶作为一种非常有潜力的生物标志物得到了越来越多的关注。本文总结了基质金属蛋白酶在肿瘤、心血管疾病、炎症性疾病和神经退行性疾病等疾病诊断中的应用,并对基于RNA水平、蛋白质水平和MMPs的水解酶活性的3类检测方法进行了介绍,以期为基质金属蛋白酶检测的临床应用提供理论参考。
    Abstract: Recently,an increasing number of studies have found that matrix metalloproteinase (MMPs) are closely related to the severity,diagnosis and prognosis of a variety of diseases. MMPs have therefore also gained increasing attention as a potential biomarker. In this paper,the application of MMPs in the diagnosis of tumors,cardiovascular diseases,inflammatory diseases and neurodegenerative diseases was summarized,and three types of detection methods based on RNA level,protein level and hydrolase activity of MMPs were introduced,which aims to provide some theoretical reference for the study of clinical application of MMPs detection.
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出版历程
  • 收稿日期:  2019-11-26
  • 修回日期:  2020-08-04
  • 刊出日期:  2020-10-24

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