| [1] |
. Nature，2019，576（7785）：51?60.
|
| [2] |
Rines AK，Sharabi K，Tavares CD，et al. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes［J］. Nat Rev Drug Discov，2016，15（11）：786?804.
|
| [3] |
Gray SM，Page LC，Tong J. Ghrelin regulation of glucose metabolism［J］. J Neuroendocrinol，2019，31（7）：e12705. doi：10.1111/jne.12705.
|
| [4] |
Yang J，Wu L，Zhou LZ，et al. MiR-96 promotes insulin biosynthesis and secretion in mouse β cells through targeting Sox6［J］. J Pract Med（实用医学杂志），2019，35（2）：196?200.
|
| [5] |
Villamayor L，Rodríguez-Seguel E，Araujo R，et al. GATA6 controls insulin biosynthesis and secretion in adult β-cells［J］. Diabetes，2018，67（3）：448?460.
|
| [6] |
Dalmas E. Innate immune priming of insulin secretion［J］. Curr Opin Immunol，2019，56：44?49.
|
| [7] |
Xiao XW，Gaffar I，Guo P，et al. M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7［J］. Proc Natl Acad Sci U S A，2014，111（13）：E1211?E1220.
|
| [8] |
Criscimanna A，Coudriet GM，Gittes GK，et al. Activated macrophages create lineage-specific microenvironments for pancreatic acinar- and β-cell regeneration in mice［J］. Gastroenterology，2014，147（5）：1106?1118.e11.
|
| [9] |
Dalmas E，Lehmann FM，Dror E，et al. Interleukin-33-activated islet-resident innate lymphoid cells promote insulin secretion through myeloid cell retinoic acid production［J］. Immunity，2017，47（5）：928?942.e7.
|
| [10] |
Zhang Q，Pan Y，Zeng BH，et al. Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells［J］. Cell Res，2019，29（7）：516?532.
|
| [11] |
Jiang YL，Huang W，Wang J，et al. Metformin plays a dual role in MIN6 pancreatic β cell function through AMPK-dependent autophagy［J］. Int J Biol Sci，2014，10（3）：268?277.
|
| [12] |
Drucker DJ，Nauck MA. The incretin system：glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes［J］. Lancet，2006，368（9548）：1696?1705.
|
| [13] |
Yoon JW，Jun HS. Autoimmune destruction of pancreatic beta cells［J］. Am J Ther，2005，12（6）：580?591.
|
| [14] |
Haythorne E，Rohm M，van de Bunt M，et al. Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells［J］. Nat Commun，2019，10（1）：2474.
|
| [15] |
Zhang EM，Mohammed Al-Amily I，Mohammed S，et al. Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells［J］. Cell Metab，2019，29（1）：64?77.e6.
|
| [16] |
Cheng FR，Cui HX，Fang JL，et al. Ameliorative effect and mechanism of the purified anthraquinone-glycoside preparation from Rheum palmatum L. on type 2 diabetes mellitus［J］. Molecules，2019，24（8）：E1454.
|
| [17] |
Brooks-Worrell BM，Palmer JP. Setting the stage for islet autoimmunity in type 2 diabetes：obesity-associated chronic systemic inflammation and endoplasmic reticulum （ER） stress［J］. Diabetes Care，2019，42（12）：2338?2346.
|
| [18] |
McCullough KD，Martindale JL，Klotz LO，et al. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state［J］. Mol Cell Biol，2001，21（4）：1249?1259.
|
| [19] |
Lipson KL，Fonseca SG，Ishigaki S，et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1［J］. Cell Metab，2006，4（3）：245?254.
|
| [20] |
Odisho T，Zhang LL，Volchuk A. ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells［J］. Exp Cell Res，2015，330（1）：111?122.
|
| [21] |
Duan HL，Lee JW，Moon SW，et al. Discovery，synthesis，and evaluation of 2，4-diaminoquinazolines as a novel class of pancreatic β-cell-protective agents against endoplasmic reticulum （ER） stress［J］. J Med Chem，2016，59（17）：7783?7800.
|
| [22] |
Duan HL，Li Y，Arora D，et al. Discovery of a benzamide derivative that protects pancreatic β-cells against endoplasmic reticulum stress［J］. J Med Chem，2017，60（14）：6191?6204.
|
| [23] |
Meier JJ，Butler AE，Saisho Y，et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans［J］. Diabetes，2008，57（6）：1584?1594.
|
| [24] |
Kumar A，Katz LS，Schulz AM，et al. Activation of Nrf2 is required for normal and ChREBPα-augmented glucose-stimulated β-cell proliferation［J］. Diabetes，2018，67（8）：1561?1575.
|
| [25] |
El Ouaamari A，O-Sullivan I，Shirakawa J，et al. Forkhead box protein O1 （FoxO1） regulates hepatic serine protease inhibitor B1 （serpinB1） expression in a non-cell-autonomous fashion［J］. J Biol Chem，2019，294（3）：1059?1069.
|
| [26] |
Wang P，Alvarez-Perez JC，Felsenfeld DP，et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication［J］. Nat Med，2015，21（4）：383?388.
|
| [27] |
Shen WJ，Taylor B，Jin QH，et al. Inhibition of DYRK1A and GSK3B induces human β-cell proliferation［J］. Nat Commun，2015，6：8372.
|
| [28] |
Rachdi L，Kariyawasam D，Guez F，et al. Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass［J］. Diabetologia，2014，57（5）：960?969.
|
| [29] |
Rutter GA，Pullen TJ，Hodson DJ，et al. Pancreatic β-cell identity，glucose sensing and the control of insulin secretion［J］. Biochem J，2015，466（2）：203?218.
|
| [30] |
Pagliuca FW，Millman JR，Gürtler M，et al. Generation of functional human pancreatic β cells in vitro［J］. Cell，2014，159（2）：428?439.
|
| [31] |
Veres A，Faust AL，Bushnell HL，et al. Charting cellular identity during human in vitro β-cell differentiation［J］. Nature，2019，569（7756）：368?373.
|
| [32] |
Navarro-Tableros V，Gomez Y，Brizzi MF，et al. Generation of human stem cell-derived pancreatic organoids （POs） for regenerative medicine［J］. Adv Exp Med Biol，2020，1212：179?220.
|
| [33] |
Saxena P，Heng BC，Bai P，et al. A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells［J］. Nat Commun，2016，7：11247.
|
| [34] |
Sancho R，Gruber R，Gu GQ，et al. Loss of Fbw7 reprograms adult pancreatic ductal cells into α，δ，and β cells［J］. Cell Stem Cell，2014，15（2）：139?153.
|
| [35] |
Lin HT，Kao CL，Lee KH，et al. Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method［J］. World J Gastroenterol，2007，13（11）：1672?1679.
|
| [36] |
Rovira M，Huang W，Yusuff S，et al. Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation［J］. Proc Natl Acad Sci U S A，2011，108（48）：19264?19269.
|
| [37] |
Cao LJ，Zhu KN，Jiang CH，et al. Intervention effects of the extract of Alismatis Rhizoma on streptozotocin-induced type 2 diabetic rats［J］. J China Pharm Univ（中国药科大学学报），2017，48（5）：601?608.
|
| [38] |
Xu ZM，Zhu JJ，Jiang ZZ，et al. Hypoglycemic effects of terpenes from Fructus Corni on db / db diabetic mice［J］. J China Pharm Univ（中国药科大学学报），2016，47（3）：337?341.
|
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