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芬太尼类物质研究进展

陈园园, 李香豫, 许鹏飞, 卢晓鵾, 王优美, 徐鹏, 狄斌

陈园园, 李香豫, 许鹏飞, 卢晓鵾, 王优美, 徐鹏, 狄斌. 芬太尼类物质研究进展[J]. 中国药科大学学报, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612
引用本文: 陈园园, 李香豫, 许鹏飞, 卢晓鵾, 王优美, 徐鹏, 狄斌. 芬太尼类物质研究进展[J]. 中国药科大学学报, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612
Chen Yuanyuan, Li Xiangyu, XU Pengfei, LU Xiaokun, WANG Youmei, XU Peng, DI Bin. Research advances of fentanyl and fentanyl-related substances[J]. Journal of China Pharmaceutical University, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612
Citation: Chen Yuanyuan, Li Xiangyu, XU Pengfei, LU Xiaokun, WANG Youmei, XU Peng, DI Bin. Research advances of fentanyl and fentanyl-related substances[J]. Journal of China Pharmaceutical University, 2020, 51(6): 724-730. DOI: 10.11665/j.issn.1000-5048.20200612

芬太尼类物质研究进展

基金项目: 十三五国家重点研究与发展计划资助项目(No.2017YFC0803605,No.2018YFC0807402)

Research advances of fentanyl and fentanyl-related substances

Funds: This study was supported by the National Key Research and Development Program of China for the 13th Five-Year Plan (No.2017YFC0803605,No.2018YFC0807402)
  • 摘要: 芬太尼类物质是以芬太尼为代表的一类人工合成的强效麻醉剂,近年来在全球多个国家中的滥用和贩卖形势较为严峻,极大威胁人们的健康和社会的安定。通过对芬太尼类物质的滥用、药理毒理作用、检测方法及管控情况等方面进行综述,提高人们对其基本性质、研究现状以及管控情况等方面的了解,为今后的研究提供参考。
    Abstract: Fentanyl and fentanyl-related substances are a series of synthetic and powerful anesthetics represented by fentanyl. In recent years,the abuse and trafficking of these substances in many countries around the world are serious which poses a great threat to people"s health and social stability. This paper focuses on the abuse,pharmacological and toxicological action,detection methods and control of fentanyl and fentanyl-related substances and aims to enhance people"s understanding of their basic properties,current research and control so as to provide references for future research.
  • [1] . J Beijing Police College(北京警察学院学报),2019(3):109?115.
    [2] Yang LH. Reflection on the management of the whole class of fentanyl substances in China[J]. J Yunnan Police Officer Academy(云南警官学院学报),2019(4):1?4.
    [3] Liu ZM. Abuse and control of fentanyl and its derivatives:hazards and challenges[J]. Chin J Drug Depend(中国药物依赖性杂志),2017,26(4):274?276.
    [4] UNODC. Fentanyl and its anolognes-50 year on[J]. Global SMART Update,2017,17:3?8.
    [5] Karila L,Marillier M,Chaumette B,et al. New synthetic opioids:part of a new addiction landscape[J]. Neurosci Biobehav Rev,2019,106:133?140.
    [6] Baumann MH,Pasternak GW. Novel synthetic opioids and overdose deaths:tip of the iceberg[J]? Neuropsychopharmacology,2018,43(1):216?217.
    [7] UNODC. Understanding the global opioid crisis[J]. Global SMART Update,2019,21:6?9.
    [8] Burns SM,Cunningham CW,Mercer SL. DARK classics in chemical neuroscience:fentanyl[J]. ACS Chem Neurosci,2018,9(10):2428?2437.
    [9] Comer SD,Cahill CM. Fentanyl:receptor pharmacology,abuse potential,and implications for treatment[J]. Neurosci Biobehav Rev,2019,106:49?57.
    [10] Xiao JZ. Pharmacology and clinical practice of remifentanil[J]. J Med Theor Pract (医学理论与实践),2009,22(2):158?160.
    [11] Yang S,Xu Q. Research progress in the fentanyl and its derivatives in the treatment of cancer pain[J]. Shanghai Med Pharm J(上海医药),2015(5):32?36.
    [12] Pacifici GM. Clinical pharmacology of fentanyl in preterm infants. A review[J]. Pediatr Neonatol,2015,56(3):143?148.
    [13] Schaefer CP,Tome ME,Davis TP. The opioid epidemic:a central role for the blood brain barrier in opioid analgesia and abuse[J]. Fluids Barriers CNS,2017,14(1):32.
    [14] Ninkovi? J,Roy S. Role of the mu-opioid receptor in opioid modulation of immune function[J]. Amino Acids,2013,45(1):9?24.
    [15] Xu L,Li YH. Studies on pharmacological action and clinical application of sufentanil[J]. Anhui Med Pharm J(安徽医药),2011(3):375?377.
    [16] Xiao GF,Lv H. Observation on the analgesic effect and stress state of brachial plexus block combined with remifentanil during replantation of severed fingers[J]. J Logist Univ PAPF(武警后勤学院学报),2018,27(6):48?51.
    [17] Ma L,Wang XL. Evaluation of sufentanil in intravenous postoperative analgesia and clinical anesthesia[J]. Gen J Stomat(全科口腔医学杂志),2018,5(32):191?192.
    [18] Dumas EO,Pollack GM. Opioid tolerance development:a pharmacokinetic/pharmacodynamic perspective[J]. AAPS J,2008,10(4):537?551.
    [19] Sutou I,Nakatani T,Hashimoto T,et al. Fentanyl tolerance in the treatment of cancer pain:a case of successful opioid switching from fentanyl to oxycodone at a reduced equivalent dose[J]. J Pain Palliat Care Pharmacother,2015,29(2):161?165.
    [20] Neunhoeffer F,Hanser A,Esslinger M,et al. Ketamine infusion as a counter measure for opioid tolerance in mechanically ventilated children:a pilot study[J]. Paediatr Drugs,2017,19(3):259?265.
    [21] Volkow ND,Jones EB,Einstein EB,et al. Prevention and treatment of opioid misuse and addiction:a review[J]. JAMA Psychiatry,2019,76(2):208?216.
    [22] Hao W,Zhao M,Li J. Addication medicine:theory and practice(成瘾医学:理论和实践)[M]. Beijing:People''''s Medical Publishing House,2016:14?71.
    [23] Aceto M. Dependence studies of new compounds in the rhesus monkey,rat and mouse[J]. Problems Drug Dependence ,1996,1998:338.
    [24] Pan LS,Cui YY,Ren YH,et al. Dependence -producing potential of remifentanil[J]. Chin J Drug Depend(中国药物依赖性杂志),2002,11(2):107?110.
    [25] Bekhit MH. Opioid-induced hyperalgesia and tolerance[J]. Am J Ther,2010,17(5):498?510.
    [26] YueK,WenRJ. Neuroimmune mechanism of opiates addiction[J]. J Jianghan Univ(Nat Sci Ed.)[江汉大学学报(自然科学版)],2017,45(3):241?246.
    [27] Essawi MY. Fentanyl analogues with a modified propanamido group as potential affinity labels:synthesis and in vivo activity[J]. Pharmazie,1999,54(4):307?308.
    [28] Lin H,Higgins P,Loh HH,et al. Bidirectional effects of fentanyl on dendritic spines and AMPA receptors depend upon the internalization of mu opioid receptors[J]. Neuropsychopharmacology,2009,34(9):2097?2111.
    [29] Wei X,Wei W. Role of gabapentin in preventing fentanyl-and morphine-withdrawal-induced hyperalgesia in rats[J]. J Anesth,2012,26(2):236?241.
    [30] Dolinak D. Opioid toxicity[J]. Acad Forensic Pathol,2017,7(1):19?35.
    [31] Liu C,Kang Y. How to evaluate and select sedatives and analgesics considering their cardiovascular and respiratory effects[J]? Chin J Crit Care Intensive Care Med Electron Ed(中华重症医学电子杂志),2017,3(4):291?295.
    [32] Liu XB,Xu GP. Research progress of mechanism about remifentanil slowing down heart rate[J]. Med Recap(医学综述),2012,18(23):4027?4029.
    [33] Chen L,Zhao YH,Liu XL. Progress in the application of sufentanil in the treatment of cancer pain[J]. Chin J Pain Med(中国疼痛医学杂志),2018,24(11):65?68.
    [34] Guo ZF. Clinical application of sufentanil[J]. J Chengde Med Col(承德医学院学报),2016,33(6):516?519.
    [35] Qian ZH,Li P,Zheng H,et al. Mass fragmentation characteristics of fentanyl analogue[J]. J Chin Mass Spectrom Soc(质谱学报),2018,39(5):79?88.
    [36] Gupta PK,Yadav SK,Bhutia YD,et al. Synthesis and comparative bioefficacy of N-(1-phenethyl-4-piperidinyl)propionanilide (fentanyl) and its 1-substituted analogs in Swiss albino mice[J]. Med Chem Res,2013,22(8):3888?3896.
    [37] Swaminathan SK,Fisher J,Kandimalla KK. Sensitive determination of fentanyl in low-volume serum samples by LC-MS/MS[J]. AAPS Pharmscitech,2018,19(7):2812?2817.
    [38] Mochizuki A,Nakazawa H,Adachi N,et al. Identification and quantification of mepirapim and acetyl fentanyl in authentic human whole blood and urine samples by GC-MS/MS and LC-MS/MS[J]. Forensic Toxicol,2018,36(1):81?87.
    [39] Misailidi N,Athanaselis S,Nikolaou P,et al. A GC-MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation[J]. Forensic Toxicol,2019,37(1):238?244.
    [40] Liu CM. The application prospect of fourier transform infrared spectroscopy in narcotics control area[J]. Spectrosc Spectral Anal(光谱学与光谱分析),2018,38(S1):400?401.
    [41] Mallette JR,Casale JF,Toske SG,et al. Characterization of (2R,4S)- and (2R,4R)-2-Methylfentanyl and their differentiation from cis- and trans-3-methylfentanyl[J]. Forensic Chem,2018,8:64?71.
    [42] Li KK,Miao CY,Wang DK. Detection of drugs by raman spectroscopy and data analysis based on R software[J]. J Light Scat (光散射学报),2018,30(2):156?162.
    [43] Kong LC,Zuo GM,Liu GQ,et al. Surface-enhanced raman spectroscopy for trace fentanyl detection in water[J]. J Light Scat (光散射学报),2010,22(1):34?38.
    [44] Tiscione NB,Wegner K. Validation of the Neogen?Fentanyl ELISA kit for blood and urine[J]. J Anal Toxicol,2017,41(4):313?317.
    [45] Smith JS,Mochel JP,Borts DJ,et al. Adverse reactions to fentanyl transdermal patches in calves:a preliminary clinical and pharmacokinetic study[J]. Vet Anaesth Analg,2018,45(4):575?580.
    [46] Wan HN. Application and development of immunoassay in drug testing and identification[J]. J Liaoning Police Coll(辽宁警察学院学报),2018,20(2):65?69.
    [47] Center For Medical Device Evaluation. NMPA. Notice of issuance of registered designated inspection notice on 30 August,2019[EB/OL].(2019-08-30)[2019-09-12].https://www.cmde.org.cn/CL0151/19680.html.
    [48] Zaknoun H,Binette MJ,Tam M. Analyzing fentanyl and fentanyl analogues by ion mob spectrometry[J]. Int J Ion Mobil Spectrom,2019,22(1):1?10.
    [49] UNODC. Recommended methods for the identification and analysis of fentanyl and its analogues in biological specimens:manual for use by national drug analysis laboratories[EB/OL]. (2017-12-07)[2019-11-11].www.unodc.org/documents/scientific/Recommended_methods_for_the_identification_and_analysis_of_fentanyl.pdf.
    [50] Zhang WY,Lin JF,Yan J,et al. Rapid screening of fentanyl substances and their precursors without the standards[J]. J Anal Sci(分析科学学报),2019,35(5):635?642.
    [51] United States Drug Enforcement Administration. Schedules of controlled substances:temporary placement of fentanyl-related substances in schedule I[EB/OL]. (2018-02-06)[2019-11-11]. https://www.deadiversion.usdoj.gov/fed_regs/rules/2018/fr0206_4.htm.
    [52] EMCDDA. Fentanils and synthetic cannabinoids:driving greater complexity into the drug situation-An update from the EU Early Warning System[EB/OL]. (2018-06-01)[2019-11-11]. http://www.emcdda.europa.eu/publications/rapid-communications/fentanils-and-synthetic-cannabinoids-ews-update_en.
    [53] Supreme people''''s court. Notice on the issuance of the catalogue of varieties of narcotic drugs and the catalogue of psychotropic drugs[EB/OL]. (2019-11-11)[2019-11-11]. http://www.qlgl.gov.cn/show-20-5239-1.html.
    [54] China National Narcotic Control Commision. China conducts the management of four fentanyl substances such as carfentanil[EB/OL]. (2017-02-16)[2019-11-11]. http://www.nncc626.com/2017-02/16/c_129482280_5.htm.
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    1. 王田静,谭奇纹,李林蔚,于子如,于慧娟. 基于内质网应激途径探讨中医药防治非酒精性脂肪性肝病. 中西医结合肝病杂志. 2024(07): 665-669 . 百度学术

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出版历程
  • 收稿日期:  2019-10-12
  • 修回日期:  2020-10-12
  • 刊出日期:  2020-12-24

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