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儿童口服给药液体剂型研究进展

Advances in research on pediatric oral liquid dosage forms

  • 摘要: 液体制剂是目前儿童临床上常用的口服给药剂型。本文从临时配制口服液体制剂、口服液体缓控释制剂、纳米混悬剂、纳米乳剂、自纳米乳剂和以牛奶为载体的液体制剂方面对儿童口服给药液体剂型研究进展进行了综述。同时指出高效的掩味/矫味技术、安全辅料的使用、高要求的技术标准及验证策略、建立良好的工作流程管理系统,有助于开发更加安全有效且依从性更高的儿童口服给药液体制剂,为进一步深入研究儿童口服给药液体剂型提供相关理论参考。

     

    Abstract: Liquid preparations are the commonly used oral dosage forms in pediatric clinical practice.This review introduces the pediatric oral liquid dosage forms including extemporaneous preparation of oral liquid formulations, oral liquid sustained and controlled release formulations, nanosuspensions, nanoemulsions, self-nanoemulsions and milk-based liquid formulations.In addition, the efficient flavoring and taste masking technologies, using safe pharmaceutical excipients, high-demanding technical standards and verification strategies, establishing excellent workflow management systems can contribute to the development and application of pediatric oral liquid dosage forms which are safer, more effective and better compliant.This review is helpful in laying the relevant theoretical foundation for further studies on pediatric oral liquid dosage forms.

     

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