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载药脂质体包封率测定方法的研究进展

张艺, 杭太俊, 宋敏

张艺, 杭太俊, 宋敏. 载药脂质体包封率测定方法的研究进展[J]. 中国药科大学学报, 2021, 52(2): 245-252. DOI: 10.11665/j.issn.1000-5048.20210214
引用本文: 张艺, 杭太俊, 宋敏. 载药脂质体包封率测定方法的研究进展[J]. 中国药科大学学报, 2021, 52(2): 245-252. DOI: 10.11665/j.issn.1000-5048.20210214
ZHANG Yi, HANG Taijun, SONG Min. Progress in research on the determination of entrapment efficiency of liposomes[J]. Journal of China Pharmaceutical University, 2021, 52(2): 245-252. DOI: 10.11665/j.issn.1000-5048.20210214
Citation: ZHANG Yi, HANG Taijun, SONG Min. Progress in research on the determination of entrapment efficiency of liposomes[J]. Journal of China Pharmaceutical University, 2021, 52(2): 245-252. DOI: 10.11665/j.issn.1000-5048.20210214

载药脂质体包封率测定方法的研究进展

Progress in research on the determination of entrapment efficiency of liposomes

  • 摘要: 载药脂质体已经成为改善药物体内行为或实现靶向给药的重要新剂型,对其关键工艺过程和相应的关键质量属性进行研究和控制是载药脂质体研究的重要工作。包封程度的高低直接决定药物在体内的疗效,因此,包封率是脂质体的关键质量属性之一。本文对常用的包封率测定方法及其特点进行分析与比较,探讨了包封率测定时需考虑的主要因素,为载药脂质体剂型开发提供参考。
    Abstract: Liposome, a new dosage form, has become important in improving in vivo behavior of drugs or realizing targeted drug delivery. Study and control of its critical processes and quality attributes are the main challenges in the current research on liposomes. The degree of encapsulation can determine drug''s effect in vivo directly, thus entrapment efficiency (EE) has turned into one of the critical quality attributes of liposome.In this paper some methods commonly used for the determination of EE and their characteristics are summarized and analyzed, and the main factors to be considered for the determination are discussed.
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  • 被引次数: 9
出版历程
  • 收稿日期:  2020-12-27
  • 修回日期:  2021-03-08
  • 刊出日期:  2021-04-24

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