台湾狗牙花的生物碱类化学成分

Alkaloids of Ervatamia pandacaqui

摘要: 采用硅胶、Sephadex LH-20、ODS、HPLC等色谱方法进行分离纯化，从夹竹桃科植物台湾狗牙花（Ervatamia pandacaqui Pichon）枝叶中分离得到11个生物碱类化合物，根据其理化性质与波谱数据分别鉴定为voacristine 7-hydroxyindolenine（1），iboxygaine （2），19S-hydroxyibogamine （3），3-oxotabersonine （4），派利文碱（perivine，5），佩西立文（pericyclivine，6），rhazinalinol （7），geissoschizol （8），3，14-dihydroolivacine （9），瓦莱萨明碱（vallesamine，10），conolobine A（11）。化合物1 ~ 11均为首次从该植物中分离得到。

Abstract: Eleven alkaloids were isolated from the twigs and leaves of Ervatamia pandacaqui using chromatographic methods of silica gel, Sephadex LH-20, ODS, and HPLC.Their structures were elucidated by physical,chemical and spectroscopic methods and determined as voacristine 7-hydroxyindolenine (1),iboxygaine (2), 19S-hydroxyibogamine (3), 3-oxotabersonine (4), perivine (5), pericyclivine (6), rhazinalinol (7), geissoschizol (8), 3, 14-dihydroolivacine (9), vallesamine (10), and conolobine A (11), respectively.All compounds were isolated from this plant for the first time.