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增氧型纳米递送系统用于光动力治疗的研究进展

孙晨凯, 陈鑫, 程皓, 张向泽, 杨筱钰, 周建平, 丁杨

孙晨凯, 陈鑫, 程皓, 张向泽, 杨筱钰, 周建平, 丁杨. 增氧型纳米递送系统用于光动力治疗的研究进展[J]. 中国药科大学学报, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401
引用本文: 孙晨凯, 陈鑫, 程皓, 张向泽, 杨筱钰, 周建平, 丁杨. 增氧型纳米递送系统用于光动力治疗的研究进展[J]. 中国药科大学学报, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401
SUN Chenkai, CHEN Xin, CHENG Hao, ZHANG Xiangze, YANG Xiaoyu, ZHOU Jianping, DING Yang. Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy[J]. Journal of China Pharmaceutical University, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401
Citation: SUN Chenkai, CHEN Xin, CHENG Hao, ZHANG Xiangze, YANG Xiaoyu, ZHOU Jianping, DING Yang. Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy[J]. Journal of China Pharmaceutical University, 2021, 52(4): 387-397. DOI: 10.11665/j.issn.1000-5048.20210401

增氧型纳米递送系统用于光动力治疗的研究进展

基金项目: 国家自然科学基金资助项目(No.81872819,No.82073401,No.82073795)

Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy

Funds: This study was supported by the National Natural Science Foundation of China (No.81872819, No.82073401, No.82073795)
  • 摘要: 光动力治疗是一种新型非侵入性治疗手段,其原理是光敏剂经激光触发后将能量转移至氧气,生成具有细胞毒性的单线态氧,从而诱导肿瘤细胞发生凋亡或坏死。作为一种氧依赖性治疗方式,光动力治疗的抗肿瘤效果明显受限于实体瘤的乏氧微环境。因此,逆转并改善肿瘤组织的缺氧情况可显著增强光动力治疗效果。本文重点讨论纳米递送系统介导的肿瘤增氧策略的研究进展,包括氧气直接递送策略、酶催化产氧递送策略、响应型材料原位产氧递送策略和微生物体供氧递送策略,以提高光动力治疗抗肿瘤效果,为进一步研究增氧型光动力治疗纳米给药系统提供了新思路和新方案。
    Abstract: Photodynamic therapy, a new type of non-invasive treatment, is based on the principle that the photosensitizer excited by laser can transfer energy to oxygen, which generates cytotoxic singlet oxygen and thus induce tumor cell apoptosis or necrosis. As an oxygen-dependent therapy, the antitumor effect of photodynamic therapy is obviously limited by hypoxia environment of solid tumor tissue. Therefore, reversing and improving the hypoxia of tumor tissue can significantly enhance the efficacy of photodynamic therapy. This review focuses on the progress of tumor oxygenation strategy mediated by nano-delivery system, including direct oxygen delivery strategies, catalytic oxygen production strategies, responsive material in situ oxygen supply strategies and microorganism oxygen supply strategies, aiming to improve the antitumor effect of photodynamic therapy. It provides new ideas and new approaches for further study of oxygen-enchancing nano-delivery system for photodynamic therapy.
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出版历程
  • 收稿日期:  2021-05-09
  • 修回日期:  2021-05-20
  • 刊出日期:  2021-08-24

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