[1] |
. Biotechnol Adv,2015,33:1878-1896.
|
[2] |
Peng L,Yu X,Cai YF,et al. Research advances of recombinant coagulation factor VII expression and synthesizing mechanism[J].J China Pharm Univ(中国药科大学学报),2015,46(5):623-628.
|
[3] |
Hamaker NK,Lee KH. Site-specific integration ushers in a new era of precise CHO cell line engineering[J]. Curr Opin Chem Eng,2018,22:152-160.
|
[4] |
Lee JS,Grav LM,Pedersen LE,et al. Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment[J]. Biotechnol Bioeng,2016,113(11):2518-2523.
|
[5] |
Cheng JK,Lewis AM,Kim DS,et al. Identifying and retargeting transcriptional hot spots in the human genome[J]. Biotechnol J,2016,11(8):1100-1109.
|
[6] |
Yang L. Study on site-specific integration and expression of human serum albumin in CHO-K1 cell genome[D].Jiangnan University,2020.
|
[7] |
Zhou ST. Study of site-specific integration of therapeutic protein genes into CHO genome and stable expression[D].Jiangnan University,2019.
|
[8] |
Plesingerova H,Janovska P,Mishra A,et al. Expression of COBLL1 encoding novel ROR1 binding partner is robust predictor of survival in chronic lymphocytic leukemia[J]. Haematologica,2018,103(2):313-324.
|
[9] |
Chen ZF,Yu HJ,Shi X,et al. Functional screening of candidate causal genes for insulin resistance in human preadipocytes and adipocytes[J]. Circ Res,2020,126(3):330-346.
|
[10] |
Sharma V,Sharma I,Sethi I,et al. Replication of newly identified type 2 diabetes susceptible loci in Northwest Indian population[J]. Diabetes Res Clin Pract,2017,126:160-163.
|
[11] |
Park JW,Jang HJ,Shin S,et al. Molecular analysis of alternative transcripts of the equine cordon-bleu WH2 repeat protein-like 1 (COBLL1) gene[J]. Asian-Australas J Anim Sci,2015,28(6):870-875.
|
[12] |
Chauhan D,Bartok E,Gaidt MM,et al. BAX/BAK-induced apoptosis results in caspase-8-dependent IL-1beta maturation in macrophages[J]. Cell Rep,2018,25(9):2354-2368.
|
[13] |
O''Neill KL,Huang K,Zhang JJ,et al. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane[J]. Genes Dev,2016,30(8):973-988.
|
[14] |
Zhao SQ,Zhang Y,Tian H,et al. Expression and bioactivity of recombinant 3DHSA-Nartograstim fusion protein in Pichia pastoris[J]. J China Pharm Univ(中国药科大学学报),2013,44(6):577-582.
|
[15] |
Bailey LA,Hatton D,Field R,et al. Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture[J]. Biotechnol Bioeng,2012,109(8):2093-2103.
|
[16] |
Shin SW,Lee JS. Optimized CRISPR/Cas9 strategy for homology-directed multiple targeted integration of transgenes in CHO cells[J]. Biotechnol Bioeng,2020,117(6):1895-1903.
|
[17] |
Zhou ST,Ding XF,Yang L,et al. Discovery of a stable expression hot spot in the genome of Chinese hamster ovary cells using lentivirus-based random integration[J]. Biotechnol Biotec Eq,2019,33(1):605-612.
|
[18] |
Gaidukov L,Wroblewska L,Teague B,et al. A multi-landing pad DNA integration platform for mammalian cell engineering[J]. Nucleic Acids Res,2018,46(8):4072-4086.
|