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生物电子等排体双环[1.1.1]戊烷(BCP)在药物设计中的应用

黄雨, 张寅生

黄雨, 张寅生. 生物电子等排体双环[1.1.1]戊烷(BCP)在药物设计中的应用[J]. 中国药科大学学报, 2022, 53(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20220101
引用本文: 黄雨, 张寅生. 生物电子等排体双环[1.1.1]戊烷(BCP)在药物设计中的应用[J]. 中国药科大学学报, 2022, 53(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20220101
HUANG Yu, ZHANG Yinsheng. Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design[J]. Journal of China Pharmaceutical University, 2022, 53(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20220101
Citation: HUANG Yu, ZHANG Yinsheng. Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design[J]. Journal of China Pharmaceutical University, 2022, 53(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20220101

生物电子等排体双环[1.1.1]戊烷(BCP)在药物设计中的应用

基金项目: 江苏省抗病毒靶向药物研究重点实验室资助项目([2019]No.1627)

Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design

Funds: This study was supported by the Program of Jiangsu Key Laboratory of Targeted Antiviral Research ([2019]No.1627)
  • 摘要: 随着药物化学和有机化学的发展, 越来越多经典的和非经典的生物电子等排体被运用到新药的设计中。近几年来,双环[1.1.1]戊烷基团(BCP)作为苯环、叔丁基和炔烃的生物电子等排体越来越受到药物化学家和有机化学家们的广泛关注。本文综述了BCP在药物设计中的应用,旨在为新药研究人员提供参考。
    Abstract: With the development of medicinal and organic chemistry, more and more classical and non-classical bioisosteres are used in the design of novel drugs.Bicyclo[1.1.1] pentane (BCP), as a bioisostere of benzene, t-butyl and alkyne moieties,has recently received extensive attention from medicinal and organic chemists.This paper briefly reviews its application in drug design to provide reference for drug discovery researchers.
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出版历程
  • 收稿日期:  2021-06-15
  • 修回日期:  2022-01-02
  • 刊出日期:  2022-02-24

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