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原位凝胶在牙周炎治疗中的应用及其研究进展

沙康, 李佳宸, 祁小乐

沙康, 李佳宸, 祁小乐. 原位凝胶在牙周炎治疗中的应用及其研究进展[J]. 中国药科大学学报, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
引用本文: 沙康, 李佳宸, 祁小乐. 原位凝胶在牙周炎治疗中的应用及其研究进展[J]. 中国药科大学学报, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
shu
SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
Citation: SHA Kang, LI Jiachen, QI Xiaole. Application and research progress of in situ gel for local treatment of periodontitis[J]. Journal of China Pharmaceutical University, 2022, 53(3): 365-375. DOI: 10.11665/j.issn.1000-5048.20220315
shu

原位凝胶在牙周炎治疗中的应用及其研究进展

  • 中国药科大学药学院药剂系，南京 211198

Application and research progress of in situ gel for local treatment of periodontitis

  • Department of Pharmaceutics,School of Pharmacy, China Pharmaceutical University,Nanjing 211198, China

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    摘要
  • 摘要: 近年来，原位凝胶作为一种局部药物递送系统，因其良好的病灶可注入性、局部药物储库功能、药物缓释作用等特点，在牙周炎治疗中受到广泛关注，将不同类型的药物（如抗菌药物、生物活性因子等）载入原位凝胶可实现不同的治疗目的。本文总结了温度敏感型、离子敏感型、pH敏感型、溶剂交换型等各类型原位凝胶在牙周给药中的应用及局限，并对原位凝胶在消除牙周炎症、修复牙周组织以及装载微球后的长效治疗作用进行了综述。
    Abstract: Recently, in situ gel has been widely used as a local delivery system for periodontitis treatment because of its lesion injectability, local drug depot function, and drug sustained-release effect.Different therapeutic purposes can be achieved by loading different types of drugs such as antibiotics, bioactive factors, etc.In this review, different types of in situ gel with temperature-sensitive, ion-sensitive, pH-sensitive and solvent-exchanged characteristics were introduced for their applications and limitations in the delivery of drug for periodontitis;and the elimination of periodontal inflammation, periodontal tissue repair and the long-term role after loading microsphere achieved by the in situ gel system were also reviewed.
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  • 收稿日期:  2022-01-05
  • 修回日期:  2022-04-06
  • 刊出日期:  2022-06-24

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