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污水中常见毒品的分析方法优化及验证

王叶, 徐磊, 徐鹏, 杭太俊, 宋敏, 王优美, 徐慧

王叶, 徐磊, 徐鹏, 杭太俊, 宋敏, 王优美, 徐慧. 污水中常见毒品的分析方法优化及验证[J]. 中国药科大学学报, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409
引用本文: 王叶, 徐磊, 徐鹏, 杭太俊, 宋敏, 王优美, 徐慧. 污水中常见毒品的分析方法优化及验证[J]. 中国药科大学学报, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409
WANG Ye, XU Lei, XU Peng, HANG Taijun, SONG Min, WANG Youmei, XU Hui. Optimization and validation of the analytical methods to detect common illicit drugs in sewage[J]. Journal of China Pharmaceutical University, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409
Citation: WANG Ye, XU Lei, XU Peng, HANG Taijun, SONG Min, WANG Youmei, XU Hui. Optimization and validation of the analytical methods to detect common illicit drugs in sewage[J]. Journal of China Pharmaceutical University, 2022, 53(4): 467-472. DOI: 10.11665/j.issn.1000-5048.20220409

污水中常见毒品的分析方法优化及验证

Optimization and validation of the analytical methods to detect common illicit drugs in sewage

  • 摘要: 通过采集城市污水样品,分析其中毒品含量,从而监测毒品滥用情况的污水流行病学是评估毒情和打击毒品犯罪的重要技术手段。研究建立了城市污水中包含苯丙胺和吗啡在内的12种常见毒品及其代谢物的SPE-UPLC-MS/MS分析方法,优化确立了样品浓缩过程中关键的盐酸-乙腈(5∶95)酸化步骤,保障了针对这些有机氮碱性痕量成分分析的抗交叉污染性,提高了方法的稳定性、专属性和准确性。优化的方法经验证符合复杂污水样本的分析要求,并成功地应用于城市毒情评估。
    Abstract: The waste water-based epidemiology is an important technique to fight against drug abuse by analyzing the concentration of illicit drugs in urban sewage, which can monitor the abuse of drugs.An SPE-UPLC-MS/MS method was developed for the analysis of 12 common drugs and their metabolites involving amphetamine and morphine.It was shown that the best result was achieved when hydrochloric acid/ acetonitrile (5∶95) was added to acidify the sample during the concentration process, guaranteeing the anti-across contamination of the analysis of organic nitrogen basic trace components, and improve the stability, specificity, and accuracy of the method.The optimized method meets the analytical requirements of complex sewage samples, and has been successfully applied to the assessment of urban drug abuse through sewage analysis.
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出版历程
  • 收稿日期:  2021-11-10
  • 修回日期:  2022-06-01
  • 刊出日期:  2022-08-24

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