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核糖体蛋白的类泛素化修饰及其功能的研究进展

吴玥, 陈依军

吴玥, 陈依军. 核糖体蛋白的类泛素化修饰及其功能的研究进展[J]. 中国药科大学学报, 2022, 53(5): 507-517. DOI: 10.11665/j.issn.1000-5048.20220501
引用本文: 吴玥, 陈依军. 核糖体蛋白的类泛素化修饰及其功能的研究进展[J]. 中国药科大学学报, 2022, 53(5): 507-517. DOI: 10.11665/j.issn.1000-5048.20220501
shu
WU Yue, CHEN Yijun. Recent progress of functional impacts of ubiquitin-like modifications on ribosomal proteins[J]. Journal of China Pharmaceutical University, 2022, 53(5): 507-517. DOI: 10.11665/j.issn.1000-5048.20220501
Citation: WU Yue, CHEN Yijun. Recent progress of functional impacts of ubiquitin-like modifications on ribosomal proteins[J]. Journal of China Pharmaceutical University, 2022, 53(5): 507-517. DOI: 10.11665/j.issn.1000-5048.20220501
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核糖体蛋白的类泛素化修饰及其功能的研究进展

  • 中国药科大学生命科学与技术学院，南京 211198

基金项目: 国家自然科学基金资助项目（No.81973386）

Recent progress of functional impacts of ubiquitin-like modifications on ribosomal proteins

  • School of Life Science & Technology, China Pharmaceutical University, Nanjing 211198, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81973386)

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    摘要
  • 摘要: 核糖体蛋白（RP）是核糖体的组成成分，在核糖体生物合成及蛋白翻译过程中发挥重要调控作用。此外，RP在细胞中存在非核糖体功能，并可由多种形式的类泛素化修饰介导实现。RP的类泛素化修饰过程对相应RP的功能和亚细胞定位产生不同的影响，并表现出对多个生理病理过程的调控作用。本文主要对RP的SUMOylation、Neddylation和UFMylation等类泛素化系统进行介绍，并对RP的类泛素化修饰过程及其对细胞增殖、凋亡、自噬和蛋白质生命周期调控方面的影响进行总结，为相关疾病的药物治疗或干预措施带来新的启示。
    Abstract: Ribosomal proteins (RP), components of ribosomes to regulate protein biosynthesis, possess a variety of extra-ribosomal functions which can be mediated by various ubiquitination-like modifications (Ublylation).The Ublylation of RP can result in functional changes and subcellular localizations of corresponding RP, and play regulatory roles on numerous physiological and pathological processes.In this review, in addition to the introduction of Ublylation systems for RP, such as SUMOylation, Neddylation and UFMylation, we summarized recent advances in the elucidation of Ublylation processes for RP and their impacts on cell proliferation, apoptosis, autophagy and protein fate, aiming to lay a foundation for the discovery and development of novel therapeutics based on the intervention of the Ublylation processes for RP.
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