内质网应激对T细胞抗肿瘤功能调控的研究进展

王铮豪; 高亚凤; 张连军; 刘畅

doi:10.11665/j.issn.1000-5048.20220502

内质网应激对T细胞抗肿瘤功能调控的研究进展

1.
中国药科大学生命科学与技术学院，南京 211198
2.
中国医学科学院北京协和医学院苏州系统医学研究所，苏州 215123

基金项目: 国家自然科学基金资助项目（No.81971466）；江苏省杰出青年基金资助项目（No.BK20220049）

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出版历程
- 收稿日期: 2022-08-07
- 修回日期: 2022-09-19
- 刊出日期: 2022-10-24

Research progress of T cell anti-tumor function regulated by endoplasmic reticulum stress

1.
School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198
2.
Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Suzhou 215123, China

Funds: This study was supported by the National Natural Science Foundation of China (No.81971466) and the Applied Basic Research Programs of Science and Technology Commission Foundation of Jiangsu Province (No.BK20220049)

摘要

摘要: 内质网应激参与肿瘤的发生与发展，近年来，内质网应激对T细胞发育和功能调控的研究也逐渐深入。肿瘤微环境中浸润的T细胞内质网应激的发生加剧T细胞的耗竭，损害T细胞抗肿瘤免疫功能。内质网应激抑制剂的使用可以减轻T细胞的耗竭程度，改善肿瘤微环境中T细胞的抗肿瘤功能。此外，一些时钟基因如Per1和Per2的下调也促进了T细胞耗竭的进展，而内质网应激通路的效应分子能够调控生物钟网络中Per基因家族的转录，增强T细胞的免疫功能。本文就内质网应激调控T细胞的抗肿瘤功能进行论述，为肿瘤免疫治疗提供新策略。
- 内质网应激 /
- T细胞 /
- 抗肿瘤功能 /
- 进展
Abstract: Endoplasmic reticulum (ER) stress is involved in the development and progression of tumors.In recent years, great attention has been paid to the study of the interplay of ER stress and T cell differentiation and functionality.Intense ER stress in the tumor-infiltrating T cells exacerbates T cell exhaustion and impairs T cell anti-tumor immunity.Therefore, a variety of ER stress inhibitors have been developed and utilized to alleviate T cell exhaustion, which improves T cell function in tumor microenvironment.Furthermore, the downregulation of several circadian clock genes like Per1 and Per2 also aggravates T cell exhaustion, and the key downstream effector molecules in ER stress regulate the transcription of Per family, thus enhancing the T cell function.In the present manuscript, we particularly summarize how ER stress impacts the anti-tumor immunity of T cells, and further discuss potential strategies for improving tumor immunotherapy via targeting ER stress.
- endoplasmic reticulum stress /
- T cell /
- anti-tumor immunity /
- progress

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