石椒草化学成分研究

蒋崇云; 李淑聪; 武倩; 周港忠; 张春磊

doi:10.11665/j.issn.1000-5048.2023020402

石椒草化学成分研究

中国药科大学中药学院，南京 211198

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出版历程
- 收稿日期: 2023-02-03
- 修回日期: 2023-07-10
- 刊出日期: 2023-08-24

Chemical composition of Boenninghausenia sessilicarpa

School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198, China

摘要

摘要: 采用硅胶、ODS、Sephadex LH-20和制备型高效液相等色谱方法对石椒草属植物石椒草Boenninghausenia sessilicarpa全草乙醇提取物的石油醚萃取部位进行分离纯化，同时根据化合物波谱数据对单体化合物进行结构鉴定。从石油醚萃取部位共分离鉴定了15个香豆素类化合物，结构鉴定分别为：欧芹烯酮酚甲醚（1）、九里香素（2）、3-（1，1-二甲基烯丙基）-8-羟基-7-甲氧基香豆素（3）、花椒毒素（4）、异茴芹素（5）、状芸香素（6）、异去甲基呋喃羽叶芸香素（7）、欧前胡素（8）、珊瑚菜内脂（9）、白芷脑素（10）、白当归素（11）、新比克白芷内酯（12）、chalepin（13）、鲁望桔内酯（14）、3-（1，1-二甲基烯丙基）-花椒内酯（15）。化合物1 ~ 3、6 ~ 10和14 ~ 15均首次从石椒草中分离得到。
- 芸香科 /
- 石椒草 /
- 香豆素 /
- 化学成分
Abstract: The petroleum ether fraction of ethanol extracts from Boenninghausenia sessilicarpawas isolated by combination of several chromatographic methods including silica gel, ODS, and Sephadex LH-20 column chromatography, and finally purified by preparative HPLC. The structures of the isolated compounds were identified based on the spectral data. As a result, 15 coumarin compounds were isolated and identified from the petroleum ether extraction. Their structures were determined as osthenon (1), murrangatin (2), 3-(1,1-dimethylallyl)-8-hydroxy-7-methoxycoumarin (3), xanthotoxin (4), isopimpinellin (5), chalepensin (6), isodemethylfuropinarine (7), imperatorin (8), phellopterin (9), heraclenol (10), byakangelicin (11), neobyakangelicol (12), chalepin (13), luvangetin (14), 3-(1, 1-dimethylallyl)-xanthyletin (15). Among them, compounds 1 - 3, 6 - 10 and 14 -15 were firstly isolated from B. sessilicarpa.
- Rutaceae /
- Boenninghausenia sessilicarpa /
- coumarin /
- chemical compositions

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参考文献(18)

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