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石椒草化学成分研究

蒋崇云, 李淑聪, 武倩, 周港忠, 张春磊

蒋崇云, 李淑聪, 武倩, 周港忠, 张春磊. 石椒草化学成分研究[J]. 中国药科大学学报, 2023, 54(4): 468-473. DOI: 10.11665/j.issn.1000-5048.2023020402
引用本文: 蒋崇云, 李淑聪, 武倩, 周港忠, 张春磊. 石椒草化学成分研究[J]. 中国药科大学学报, 2023, 54(4): 468-473. DOI: 10.11665/j.issn.1000-5048.2023020402
JIANG Chongyun, LI Shucong, WU Qian, ZHOU Gangzhong, ZHANG Chunlei. Chemical composition of Boenninghausenia sessilicarpa[J]. Journal of China Pharmaceutical University, 2023, 54(4): 468-473. DOI: 10.11665/j.issn.1000-5048.2023020402
Citation: JIANG Chongyun, LI Shucong, WU Qian, ZHOU Gangzhong, ZHANG Chunlei. Chemical composition of Boenninghausenia sessilicarpa[J]. Journal of China Pharmaceutical University, 2023, 54(4): 468-473. DOI: 10.11665/j.issn.1000-5048.2023020402

石椒草化学成分研究

Chemical composition of Boenninghausenia sessilicarpa

  • 摘要: 采用硅胶、ODS、Sephadex LH-20和制备型高效液相等色谱方法对石椒草属植物石椒草Boenninghausenia sessilicarpa全草乙醇提取物的石油醚萃取部位进行分离纯化,同时根据化合物波谱数据对单体化合物进行结构鉴定。从石油醚萃取部位共分离鉴定了15个香豆素类化合物,结构鉴定分别为:欧芹烯酮酚甲醚(1)、九里香素(2)、3-(1,1-二甲基烯丙基)-8-羟基-7-甲氧基香豆素(3)、花椒毒素(4)、异茴芹素(5)、状芸香素(6)、异去甲基呋喃羽叶芸香素(7)、欧前胡素(8)、珊瑚菜内脂(9)、白芷脑素(10)、白当归素(11)、新比克白芷内酯(12)、chalepin(13)、鲁望桔内酯(14)、3-(1,1-二甲基烯丙基)-花椒内酯(15)。化合物1 ~ 3、6 ~ 10和14 ~ 15均首次从石椒草中分离得到。
    Abstract: The petroleum ether fraction of ethanol extracts from Boenninghausenia sessilicarpawas isolated by combination of several chromatographic methods including silica gel, ODS, and Sephadex LH-20 column chromatography, and finally purified by preparative HPLC. The structures of the isolated compounds were identified based on the spectral data. As a result, 15 coumarin compounds were isolated and identified from the petroleum ether extraction. Their structures were determined as osthenon (1), murrangatin (2), 3-(1,1-dimethylallyl)-8-hydroxy-7-methoxycoumarin (3), xanthotoxin (4), isopimpinellin (5), chalepensin (6), isodemethylfuropinarine (7), imperatorin (8), phellopterin (9), heraclenol (10), byakangelicin (11), neobyakangelicol (12), chalepin (13), luvangetin (14), 3-(1, 1-dimethylallyl)-xanthyletin (15). Among them, compounds 1 - 3, 6 - 10 and 14 -15 were firstly isolated from B. sessilicarpa.
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出版历程
  • 收稿日期:  2023-02-03
  • 修回日期:  2023-07-10
  • 刊出日期:  2023-08-24

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