生物膜仿生纳米制剂研究进展

张强; 罗曦; 包永睿; 王帅; 李天娇; 孟宪生

doi:10.11665/j.issn.1000-5048.2023020603

生物膜仿生纳米制剂研究进展

张强¹,
罗曦¹,
包永睿^1,2,3,
王帅^1,2,3,
李天娇^1,2,3,
孟宪生^1,2,3

1.
辽宁中医药大学药学院，大连 116600
2.
辽宁省中药多维分析专业创新技术中心，大连 116600
3.
辽宁省现代中药研究工程实验室，大连 116600

基金项目: 辽宁省中医药现代化研究创新团队项目（No.LT2017015）

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- 文章访问数: 342
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出版历程
- 收稿日期: 2023-02-05
- 修回日期: 2023-09-17
- 刊出日期: 2023-10-24

Research progress in biomimetic nano formulations of biofilms

ZHANG Qiang¹,
LUO Xi¹,
BAO Yongrui^1,2,3,
WANG Shuai^1,2,3,
LI Tianjiao^1,2,3,
MENG Xiansheng^1,2,3

1.
School of Pharmacy, Liaoning University of TCM, Dalian 116600
2.
Professional Innovation Technology Center for Multidimensional Analysis of Traditional Chinese Medicine, Dalian 116600
3.
Liaoning Province Modern Chinese Medicine Research Engineering Laboratory, Dalian 116600, China

Funds: This study was supported by the Project of Traditional Chinese Medicine Modernization Research and Innovation Team of Liaoning Province (No.LT2017015)

摘要

摘要: 生物膜仿生纳米制剂有低免疫原性、高靶向性以及良好的生物相容性，且可避免被内皮网状系统清除，使其在体内血液循环时间更长。本文主要综述了生物膜仿生纳米制剂的主要类型及各自的优缺点，包括肿瘤细胞膜、红细胞膜、血小板膜、白细胞膜、干细胞膜、细胞外囊泡（外泌体、微囊泡及凋亡小体）、内质网膜以及复合生物膜等。同时针对生物膜仿生纳米制剂的研究现状，对其面临的挑战以及未来发展前景进行了展望，以期为生物膜仿生纳米制剂的进一步研究提供思路。
- 仿生纳米药物 /
- 仿生递药系统 /
- 生物膜 /
- 靶向治疗
Abstract: Biomimetic nano formulations of biofilms have low immunogenicity, high targeting, and good biocompatibility, and can avoid being cleared by the endothelial reticular system, thus with in longer blood circulation time in the body.This article mainly reviews the main types as well as advantages and disadvantages of biomimetic nano formulations of biofilms, including tumor cell membranes, red blood cell membranes, platelet membranes, white blood cell membranes, stem cell membranes, extracellular vesicles (exosomes, microvesicles, and apoptotic bodies), endoplasmic reticulum membranes, and composite biofilms, with also a prospect of the challenges facing biomimetic nano formulations of biofilms and their future development based on their current research status, aiming to provide some insight for further research on biomimetic nano formulations of biofilms.
- biomimetic nano-drugs /
- bionic drug delivery system /
- biomembrane /
- targeted therapy

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文章访问数: 342
HTML全文浏览量: 15
PDF下载量: 484
被引次数: 8

生物膜仿生纳米制剂研究进展

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出版历程

Research progress in biomimetic nano formulations of biofilms

期刊类型引用(6)

其他类型引用(2)

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出版历程

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