蛋白棕榈酰化修饰在非酒精性脂肪性肝病相关疾病中作用机制的研究进展

Research progress of palmitoylation in non-alcoholic fatty liver disease and related liver diseases

摘要: 非酒精性脂肪性肝病（non-alcoholic fatty liver disease, NAFLD）已成为全球范围内威胁人类健康的重大公共卫生问题，但其发病机制复杂，新药研发困难重重，临床用药依旧匮乏。棕榈酰化是广泛发生的一种由棕榈酰基转移酶催化的蛋白质翻译后修饰，影响其稳定性、胞膜定位及功能发挥。近年来，研究表明蛋白棕榈酰化修饰与NAFLD的病程密切相关。本文对目前已报道棕榈酰化修饰在NAFLD相关疾病中作用机制作一综述，并分析GEO数据库NAFLD肝组织中棕榈酰基转移酶家族表达水平，对探寻NAFLD发病新机制具有重要意义。

Abstract: Non-alcoholic fatty liver disease (NAFLD) has become a major public health hazard threatening human health worldwide.Yet, due to its complex pathogenesis, new drug development is difficult, with still insufficient clinical medication.Palmitoylation is a universal posttranslational modification of proteins catalyzed by palmitoyltransferase, affecting their stability, membrane localization and function.Recent studies have shown that palmitoylation is closely associated with NAFLD.This review summarizes the mechanisms of palmitoylation in NAFLD and analyzes the expression levels of the palmitoyltransferase family in liver tissues of NAFLD patients from GEO database, aiming to provide important clues to explore new mechanisms for NAFLD.