高级检索

整合应激反应在中枢神经系统疾病中的研究进展

Research progress of integrated stress response in central nervous system diseases

  • 摘要: 整合应激反应是真核细胞受到细胞内外刺激后产生的适应性反应。整合应激反应激活后会抑制大部分蛋白的翻译,但会促进某些特定蛋白的翻译,以应对复杂的细胞微环境变化。大量研究发现,在多种神经系统疾病中,整合应激反应可以被疾病相关细胞应激信号所激活,并通过学习和记忆巩固、髓鞘再生、突触可塑性等过程参与疾病的发生与发展。本文总结了整合应激反应在中枢神经系统疾病中的作用、机制和可能的药物靶点,探讨了药理学手段调节整合应激反应在治疗中枢神经系统疾病的潜力,以期能够对中枢神经系统疾病的病理研究和药物开发提供参考。

     

    Abstract: Integrated stress response is an adaptive response produced by eukaryotic cells after intracellular and extracellular stimulation. The activation of integrated stress response inhibits the translation of most proteins, yet it can promote the translation of certain proteins to cope with complex cellular microenvironment changes. A large number of studies have found that in a variety of nervous system diseases, the integrated stress response can be activated by stress signals of disease-related cells and participates in the occurrence and progression of diseases through processes such as learning and memory consolidation, myelin regeneration and synaptic plasticity. This article summarizes the role, mechanism and possible drug targets of integrated stress response in central nervous system diseases and discusses the potential of pharmacological methods to regulate integrated stress response in the treatment of central nervous system diseases, in order to provide reference for pathological research on and drug development for central nervous system diseases.

     

/

返回文章
返回