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调控小胶质细胞干预阿尔茨海默病的研究进展

Research advances in modulating microglia for intervening in Alzheimer’s disease

  • 摘要: 阿尔茨海默病(Alzheimer’s disease, AD)是世界上最常见的以痴呆为主要表现形式的神经退行性疾病。以免疫细胞小胶质细胞为靶点的病理调控在治疗AD方面显示出独特优势,能够在早期阻止AD的病理进展。本文首先概述小胶质细胞在AD发病机制中的作用,然后总结小胶质细胞在AD中与常见关键病理Aβ、tau蛋白、神经炎症以及能量代谢障碍的关系,最后综述基于小胶质细胞为靶点以逆转AD病理的可行干预策略,并探讨各项研究目前仍需要改进的问题,旨在加深对调控小胶质细胞干预AD病理的策略了解,为 未来AD患者的早期干预和治疗提供新的思路。

     

    Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world with dementia as its main manifestation. The pathological regulation strategies based on microglia in immune cells have shown their unique advantages in treating AD by preventing the pathological progression of AD at an early stage. This paper firstly introduces the role of microglia in the pathogenesis of AD, then summarizes the relationship between microglia and the common key pathologies of Aβ, tau proteins, neuroinflammation, and impaired energy metabolism in AD, and finally reviews feasible microglia-targeted intervention strategies against AD with some discussion about some current issues for improvement in each study, in the hope of deepening the understanding of strategies that regulate microglia to block AD pathology and providing some new ideas for the early intervention and treatment of AD patients in the future.

     

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