摘要:
本文对云芝菌体多糖(PV-1)及滤液多糖(PV-4)作了抗肿瘤及对免疫功能的影响等实验研究。结果,两种多糖均使小鼠胸腺缩小,脾重增加,并有提高巨噬细胞吞噬的作用。但抑瘤作用较弱。PV-1能增强戊巴比妥钠的作用,使小鼠睡眠时间延长。两种多糖毒性均很小,小鼠腹腔注射 LD50 PV-1为2750mg/kg,PV-4 2883mg/kg。
Abstract:
Inhibition of polysaccharides on sarcoma 180 and the immune response of polysaccharides were studied.Polysaccharides of polystictus versicolor used in this experiment were obtained from its mycelium ( PV -1 ) and culture medium ( PV -4 ) . when the polvsaccharides were administered intraperitoneally in daily dose of 10-100mg/kg to sarcoma 180 bearing mice for 10 to 35 days, it was found to have a faint inhibition. PV - 4 couLd not potentiate the inhibition of cyclophosphamide on sarcoma 180, on the contrary it decreased the effect, when daily dose 200mg/kg of polysaccharides was continued for 3 days, they have caused infant mice to lose the thymus weight but to gain the spleen weight. PV - 1 prolong the time of sleeping induced by pentobarbtal.In the normal mice, as well as in these mice suffering from impaired liver caused by carbontetrachloride, when PV - 1 was administered subcutaneously in dose of 100mg/kg for 7 days, it has been found to enhance the phagocytosis of microphage,Studies of acute toxicity have shown that the LD50 of PV - 1 is 2750 mg/kg, PV - 4is 2883 mg/kg for intraperitoneal administration in mice,
下载:
