穿心莲中一种新二萜内酯甙的分离和鉴定

Isolation and Identification of New Glucoside-Bicyclic Diterpenoic Lactone Derived From Andrographis Paniculata Nees

摘要: 从穿心莲叶中分离得一种新的二萜内酯甙,C_(26)H_(40)O_9,M~ 496,mp187°～188℃,根据化学和光谱数据(UV,IR,NMR,MS),酶水解,确定其结构为19-O-β-D-吡喃葡萄糖基脱氧穿心莲内酯(19-O-β-D-glucopyranosyl-deoxyandrographolide),命名为宁穿心莲内酯(Ninandrographolide,V1)。

Abstract: From the leaves of Andrographis Paniculata Nees, a new glucoside of bicyclic diterpenoic lactone was isolated. It is a white crystal (Ⅵ), C_26 H_40 O_9,M~ 496, mp 187°～188℃. On the basis of chemical and spectral data(IR, UV, NMR, MS), and enzymatic hydrolysis. The structure is assigned as 19-O-β-D-glucopyranosyl-deoxyandrographolide and named Ninandrographolide.