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丹参酮对结核杆菌的抑菌活性与层析参数酮R_M值的关系

The Relationship Between the R_M Value and Biological Activity of Tanshinones

  • 摘要: 本文报道了丹参酮类化合物对抗酸性分枝杆菌607、溃疡分枝杆菌及人型结核杆菌 H_(37)R_V 的最低抑菌浓度,并进一步研究了丹参酮在不同固定相中的层析参数 R_M 值与抑菌活性的关系。

     

    Abstract: The antibacterial data of eight diterpnoides of Danshen, (the root of Salvia Mil-tiorrhiza Bunge) are presented. The tested bacteria ares Mycobacterium 607, M. tuberculosis H_37R_V and M. trioerans. The minimal iinhibitory concentrations of these compounds range from 0.3125μg/mlto over 5μg/ml. All Tanshinones combind with plasma protein to varying degree and tuberoulostatio activity decreases from eight to twenty times. The R_M vales of Tanshinones have been determined in both different stationary phases and mobile phase. The relationship between the R_M valus and tuberculostatio activity of Tanshinones has been discussed.

     

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