国产释放仪的性能研究
PERFORMANCE STUDY OF DOMESTIC MADE DISSOLUTION APPARATUS
-
摘要: 本文选用了国内3家药厂和 Merck Sharp and Dohme 药厂生产的氢氯噻嗪(25mg)片(Lot A 3120)对3种国产释放仪(黄海转篮式、武进循环式、武进转篮式)在灵敏度、分辨力、重现性和相关性等方面进行了性能考察。结果表明:国产各释放仪的灵敏度、分辨力都很高,各仪器间的相关性极显著,重现性接近。国产释放仪与 Beckman 25-7型释放仪之间无显著性差异(P>0.05),相关性极显著(α=0.01)。某些项目的参数,国产释放仪己接近或超过 Beckman 25-7型释放仪。Abstract: The performance of three domestie-made dissolution apparatus in two types was studied by determining the dissolution rate of hydrochlorothiazide tablets. The sensitivity, discriminating ability and repreducibility of the three apparatus were studied in comparision with those of Beckman 25-7. The results obtained are comparable. No significant difference in data is found (p>0.05)and the correlation is significant(α=0.01).