胰岛素直肠给药剂型研究 Ⅱ.表面活性剂 NO-10对促进胰岛素栓在家兔体内吸收的影响
Biopharmaceutical studies on insulin rectal dosage form . The effect of the surfactant NO-10 on rectal absorption of insulin suppositories in rabbits.
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摘要: 在研究了50 IU/kg(家兔体重)以上剂量的胰岛素栓直肠给药能降低家兔血糖和某些表面活性剂具促进吸收的作用后,本文报导了含有1%表面活性剂 NO—10,剂量为75、50、30、10、5、3 IU/kg 的胰岛素可可豆油栓剂直肠给药后家兔的血糖变化。研究结果表明,75 IU/kg 和50IU/kg 剂量的胰岛素栓能使家兔产生抽搐甚至死亡,30和10IU/kg 的剂量也导致动物在实验期间内(6.0hr)血糖不能回升,5IU/kg 的剂量给药2和6小时后可使家兔血糖分别下降79%和33%。3 IU/kg 剂量的胰岛素栓在给药1.5和6.0小时时使家兔血搪分别下降65%和24%,与对照组相比,作用非常显著(P<0.001)。Abstract: The blood sugar level decrese produced by rectal administration of insulin sup-positories was studied in rabbits.Insulin suppositories were prepared with cocoa butterand 1% surfactant NO-10.The different doses of insulin investigated were 75,50,30,10,5 and 3IU/kg.The dose of 75IU/kg and 50IU/kg severely reduced the rabbits blood sugar, thus probably causing the animals convulsion and even death. The blood sugar level once reduced by the doses of 30 and 10 IU/kg could no longer increase in 6.0 hr at 2 hr and 6 hr after administration of insulin suppositories(5 IU/kg), the blood sugar level was reduced by 79% and 33% respectively.The blood sugar level decreased at 1.5 and 6.0 hr after administration of 3IU/kg were 65% and 24% respectively. The data thus obtained were significantly different (P<0.001) from those of control group.
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