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东莨菪碱麻醉作用与脑内单胺介质

SCOPOLAMINE-INDUCED ANAESTHESIA AND MONOAMINE TRANSMITTERS IN RAT BRAIN

  • 摘要: 脑室注射东莨菪碱的麻醉作用,使脑内5-羟色胺(5-HT)及5-羟吲哚乙酸(5-HIAA)显著增多。L-色氨酸负荷(400mg/kg.ip)能延长小鼠麻醉时间(P<0.01);而对氯苯丙氨酸耗竭大鼠脑内5-HT及5-HIAA后,未能消除麻醉作用。东莨菪碱还提高了大鼠中脑多巴胺含量,而去甲肾上腺含量未见明显改变。脑内5-HT系统的增强可以协同东莨菪碱的麻醉作用,但5-HT系统功能的完整性并不是这种麻醉作用的必要条件。并提示脑内M胆碱受体可能促进色胺能神经元的传递功能。

     

    Abstract: The level of 5-hydroxytryptophamine(5-HT)and 5-hydroxyindole acetic acid (5-HIAA) in rat brain was significantly incroased during the anaesthetic period induced by scopolamine intracerebroventricularly. The duration of anaesthesia by scopolamine in mice was markedly prolonged as the result of the loading dose of L—tryptophan (400mg/kg ip) . However, the anaesthetic effect was not abolished despite the depletion of 5-HT and 5-HIAA in rat brain after p—chlorophenylalanine. It was also noticed that the level of dopamine in midbrain was raised, but no significant change of noradrenaline level was observed. Potentiation of 5—HT system in rat brain could synergise the anaesthetic effect of scopolamine but it did not seem that the functional normality of 5—HT system in the brain was requisite to create this kind of anaesthesia. It was also suggested that the transmitting function of tryptophanergic neurones in the brain might be accelerated by M-cholinergic receptor.

     

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