环扁桃酯与菸酸环扁桃酯的药理比较研究

COMPARATIVE STUDY ON THE PHARMACOLOGY OF CYCLANDELATE AND NICOTINOYL CYCLANDELATE

摘要: 静脉注射环扁桃酯与菸酸环扁桃酯对麻醉狗内颈动脉灌注压、股动脉血压皆有降低作用。在低剂量时菸酸环扁桃酯作用比环扁桃酯强,大剂量则作用不如环扁桃酯强。二药皆可显著增加离体免心的冠脉流量和对抗BaCl_2对冠脉的收缩作用以及解除乙酰胆碱引起豚鼠离体回肠的强直收缩作用,但环扁桃酯作用比菸酸环扁桃酯强。静脉注射小鼠LD_(50)表明,菸酸环扁桃酯毒性较低,但腹腔注射毒性比环扁桃酯高。
- 环扁桃酯 /
- 菸酸环扁桃酯 /
- 血管扩张剂
Abstract: The results of comparative study showed that the perfusion pressure of cerebral blood vessels and the blood pressure of femoral artery were lowered by both cyclandelate( I ) and nicotinoyl cyclandelate( Ⅱ )given intravenously in anaesthetized dogs. The hypotensive action of Ⅱwas stronger than that of I at lower doses (1mg/kg, 3mg/kg) , but the maximal effect of Ⅱat higher dose (6mg/kg) was not as active as that of I. The volume flow of coronary system wag significantly increased by both I and Ⅱin isolated rabbit heart,l and Ⅱalso could antagonize the BaC12 induced constraction of coronary vessel. The spasmodic action of Ach on isolated guinea—pig ileum was decreased by I and Ⅱ.The effect of I was more potent.However, the toxicity of Ⅱ was less than I when given intravenously.
- Cyclandelate /
- Nicotinoyl cyclandelate /
- Vasodilator