Abstract: Cefmenoxime was synthesized by a four-step method with overall yield of 35.80%. The conversion of 7-ACA to 7-ACT with 1-methyl-1H-tetrazole-5-thiol, the condensation of the side-chain 2-(2-chloroacetamidothiazol-4-yl)-(Z)-2-me- thoxyimino-acetic acid with