青霉素扩环合成唑啉头孢菌素
CONVERSION OF PENICILLIN INTO CEFAZOLIN
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摘要: 用3-溴甲基头孢烯酸二苯甲酯-S-氧化物(Ⅰ)合成了唑啉头孢菌素。(Ⅰ)为研制C_(10)~-取代头孢菌素的关键中间体,从苄基青霉素转化而来。Abstract: CefaZolin was prepared from 3 -bromomethylcephembenzhydry(?)esler S-oxide which is an important intermediat for synthesis of C_(10)-substituted cephalosporins.
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