2—(2—氯乙酰氨基噻唑—4)—Z—2—甲氧亚胺乙酸的合成

SYNTHESIS OF 2-(2-CHLOROACETAMIDOTHIAYOL-4-YL)-(Z)-2-METHOXYIMINO ACETIC ACID

摘要: 以乙酰乙酸乙酯为起始原料,以氯乙酰基为氨基保护基经六步反应合成了2-(2-氯乙酰氨基噻唑-4)-(Z)-2甲氧亚胺乙酸。其顺式异构体的总收率达42.56％,该化合物为制备氨噻肟唑头孢菌素和类似头孢菌素的重要中间原料。

Abstract: 2 - (2 -Chloroacetamidothiazol-4 -yl) - (Z) -2 -methoxyimino acetic acid was synthesized by a six-step method with ethyl acetoacetate as starting meterial. The total yield of the synisomer was increased to 42. 56%.