6-取代香豆素-3-甲酰胺头孢菌素的合成

SYNTHESIS OF 7-(6-SUBSTITUTED-COUMARIN-3-FORMAMIDO)-CEPHALOSPORIC ACID DERIVATIVES

摘要: 文献报道某些6-取代香豆素-3-羧酸类化合物及其衍生物具有较强的生物活性或抗菌活性,本文合成了14个新的6-取代香豆素-3-甲酰胺头孢菌素化合物,由红外光谱、元素分析和核磁共振谱确证其化学结构。经抗菌试验,结果表明多数化合物对受试的革兰氏阳性菌有不同程度的抗菌作用,但对革兰氏阴性菌无效。

Abstract: t was reported that some derivatives of 6-substituted coumarin-3-car-boxylic acid exhibited antibiotic activity.14 new 7-(6-substituted-coumarin-3-formamido)-cephalosporic acid derivatives were then prepared with anacid chloride method and their chemical