~3H-DL-四氢巴马汀在大鼠体内的分布和排泄
DISTRIBUTION AND EXCRETION OF ~3H-DL-TETRAHYDROPALMATINE IN RATS
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摘要: 本文用~3H-DL-四氢巴马汀作示踪剂,研究了四氢巴马汀在大鼠体内的分布和排泄。实验结果表明,静注给药后,药物广泛分布于肾、肝、肺、心和脑组织中。而且脑组织内的放射性活性高于血液,证明此药可以透过血脑屏障。药物通过尿和粪便排泄,给药后136h,经尿排出的放射性活性为给药量的70%,而从粪便中排出的放射性活性则为15%。Abstract: The distribution and excretion of ~3H-DL-tetrahydropalmatine(~3H-DL-THP)in rats were studied using tracer amount of ~3H-DL-THP.Thetritiated compound was found widely distributed in heart,liver,lung,kidney and brain after intraveneous administration.The fa
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