口服炎痛静溶液体内药动学研究
PHARMACOKINETIC STUDY ON BENZYDAMINE HYDROCHLORIDE IN MEN
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摘要: 本文用荧光分光光度法测定了6名健康受试者单剂量口服炎痛静溶液50mg后血药浓度。用NONLIN程序计算机对数据进行药物动力学模型嵌合,求得炎痛静体内动力学参数为:吸收速率常数Ka1.3331h~(-1),消除速率常数K0.0706h~(-1),表观分布容积V74.18L。Abstract: The plasma levels of six healthy abult volunteers following the administration of single oral dose(50mg)Benzydamine Hydrochloride were deter-mined by fluorimetry.The pharmacokinetic parameters were fitted by non-linear least square method with TRS-80 comp