5-氟尿嘧啶非环核苷衍生物及类似物的合成
SYNTHESIS OF ACYCLONUCLEOSIDE DERIVATIVES AND ANALOGUES OF 5-FLUOROURACIL
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摘要: 本文合成了25个5-氟尿嘧啶的非环核苷衍生物及类似物,以寻找毒副反应小,安全范围广的新5-氟尿嘧啶类抗肿瘤药。以2,4-双三甲基硅烷-5-氟尿嘧啶或1-苯磺酰基-4-三甲基硅烷-5-氟尿嘧啶和各种氯甲基烷醚为原料,用碘化钠或无水四氯化锡作催化剂,在乙腈中进行缩合而得。Abstract: Twenty five Acyclonucleoside derivatives and analogues of 5-Fluoro-uracil were synthesised in order to search for novel 5-fluorouracil deriva-tive as antineoplastic agents with less side effect and broader margin ofsafety.Condensation of 2,4-bis(
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