不对称1,8-二羟基-9,10-蒽醌化合物的单甲基化反应
MONOMETHYLATION OF UNSYMMETRICAL 1,8-DIHYDROXY-9,10-ANTHRAQUINONES
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摘要: 本文以硫酸二甲酯、重氮甲烷和碘甲烷-氧化银为甲基化试剂,对芦荟大黄素、大黄酸甲酯和1,8-二羟基-3-乙酸甲酯-9,10-蒽醌三个结构不对称化合物的C_1和C_8羟基进行单甲基化反应。研究了这些异构体的分离方法,并应用核磁共振NOE效应确定了甲氧基在蒽醌母核上的位置。Abstract: The monomethylation of the hydroxy groups of the unsymmetrical 1,8 dihydroxy-9, 10-anthraquinones was studied. Dimethyl sulfate, diazomethane and methyl iodide-silver oxide were used as methylating agents to react with aloe emodin, rhein methyl ester and
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