不对称1,8-二羟基-9,10-蒽醌化合物的单甲基化反应

MONOMETHYLATION OF UNSYMMETRICAL 1,8-DIHYDROXY-9,10-ANTHRAQUINONES

摘要: 本文以硫酸二甲酯、重氮甲烷和碘甲烷-氧化银为甲基化试剂,对芦荟大黄素、大黄酸甲酯和1,8-二羟基-3-乙酸甲酯-9,10-蒽醌三个结构不对称化合物的C_1和C_8羟基进行单甲基化反应。研究了这些异构体的分离方法,并应用核磁共振NOE效应确定了甲氧基在蒽醌母核上的位置。
- 单甲基化反应 /
- NOE效应 /
- 不对称1,8-二羟基-9,10-蒽醌
Abstract: The monomethylation of the hydroxy groups of the unsymmetrical 1,8 dihydroxy-9, 10-anthraquinones was studied. Dimethyl sulfate, diazomethane and methyl iodide-silver oxide were used as methylating agents to react with aloe emodin, rhein methyl ester and
- Monomethylation /
- NOE effect /
- Unsymmetrical 1,8-dihydroxy-9,10-anthraquinones