高级检索

九里香皮抗生育物质的分离、效价与毒性

ISOLATION, ACTIVITY AND TOXICITY OF THE ACTIVE SUBSTANCES OF ANTIFERTILITY FROM MURRAYA PANICULATA

  • 摘要: 本实验以不同方法从九里香Murraya paniculata(L.)Jacks皮分离9种抗生育有效物质,并比较其效价和毒性。其中以Sephadex G_(100)柱层析-CTAB络合物(V)和不络合物(Ⅶ)、磷酸氢钙吸附酸溶-CTAB络合物(Ⅶ)、Sephadex G_(100)柱层析-磷酸氢钙吸附酸溶-CTAB不络合物(Ⅷ)及Sephadex G_(100)柱层析-磷酸氢钙吸附酸溶-Sephadex G_(200)柱层析物(Ⅸ)等5种分离物的抗生育效果显著,小鼠腹腔注射有效剂量分别为1.0,1.0,0.5,0.2和0.06mg/30g;小鼠腹腔注射给药LD_(50)分别为21,56,31,24和9.3mg/20g。狗的亚急性毒性试验,尿常规、血象、肝功能和肾功能均正常,重要脏器的病理学检查,均未发现有与药物有关的病变。豚鼠抗原性试验也未见有过敏症状发生。但家兔热源试验阳性。化合物Ⅵ初步用于临床中期妊娠引产,8例中7例有效,但也有发热发冷副反应。

     

    Abstract: Comparison of the activity and toxicity of the active substances of antifertility, isolated from the cortex of Murraya paniculata with ten methods was made. Five active substances among them were better, they were: Sephadex G_(100) chromatography-CTAB com

     

/

返回文章
返回