哌吡酮中间体—环合物的薄层-紫外分光光度法

DETERMINATION OF INTERMEDIATE (CYCLIC PRODUCT) OF PIRENZEPINE BY TLC-UV SPECTROPHOTOMETRY

摘要: 5,6-二氢-6-氧代-11H-吡啶骈2,3b1,4苯骈二氮杂(简称环合物)为抗消化性溃疡药盐酸哌吡酮的中间体,其含量测定方法未见报道。为了协助药品生产选取最佳合成反应条件,降低成本提高收率,本文对其定理分析方法进行了研究。

Abstract: Silica gel G TLC plate with n-heptane-ethyl acetate-absolute alcohol (5:5:1) as developing solvent was employed for separating the intermediate of pirenzepine synthesis, 5, 6-dihydro-6-oxy-11-hydropyrido 2, 3b 1, 4 -benzodiazepine (Cyclic product), fr