硝酸甘油贴片的药效学研究

PHARMACODYNAMIC ACTION OF LONG-ACTING TRANSDERMAL DISK OF NITROGLYCERIN

摘要: 硝酸甘油系目前防治心绞痛的常用药,由于肝脏首过效应,常须舌下给药,药效不过10～30min,长效硝酸酯类如硝酸异山梨醇酯和硝酸戊四醇酯等需大剂量口服,维持药效仅3～4h,效果未臻满意。为了延长药效,有报道制成硝酸甘油软膏及透皮释放膜剂
- 硝酸甘油 /
- 透皮贴片 /
- 药效学 /
- 血压 /
- 心率
Abstract: The long-acting transdermal disk of nitroglycerin (Nitrogum), containing nitroglycerin 20 mg, was studied on rabbits and volunteers. It showed an excellent systemic hypotensive action on both subjects with stable long-acting effect. Blood pressure was dec
- Nitroglycerin /
- Long-acting transdermal disk /
- Nitrogum /
- Pharmacodynamies /
- Hypotensive action /
- Heart rate