反相高效液相色谱法测定非诺贝特(Procetofene)
DETERMINATION OF THE IMPURITIES AND CONTENT OF PROCETOFENE BY REVERSED-PHASE HPLC
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摘要: 非诺贝特(Fenoibrate)又名普鲁脂芬(Procetofene),化学名为2-(4-对氯苯甲酰)苯氧基-2-甲基丙酸异丙酯,是目前较为理想的降血酯药。据报道,它的药效比安妥明强,毒副作用小。关于非诺贝特的含量测定,国内上海药品标准采用水解后酸碱剩余滴定法,但此法专一性不强。本文用反相高效液相色谱法分离并用对照品鉴别,测得非诺贝特合成产品的杂质是4-氯-4-羟苯酰苯(Ⅰ)和2-(4-对氯苯甲酰)苯氧基-2-甲基丙酸(Ⅱ);以4—氯苯Abstract: Reversed-phase HPLC method on a Lichrosorb 5 RP 18 analytical column, with CH_3OH-H_2O(77:23) as eluent, was established to determine the content of Procetofene (Fenofibrate) and the impurities in synthetic Procetofene. Two impurity's peaks were identifie
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