用骨架包埋工艺制备对乙酰氨基酚咀嚼片

PREPARATION OF PARACETAMOL CHEWABLE TABLETS BY MATRIX-MASKING TECHNOLOGY

摘要: 本文研究用CAP和虫胶为骨架材料包埋对乙酰氨基酚,能较好地掩盖药物的苦味。所介绍的振荡提取法测定骨架内药物含量,准确性达95%以上。体外溶出试验证实药物从骨架内释放是完全的。本法制备的对乙酰氨基酚咀嚼片具有独特的优点。

Abstract: The purpose of this study is to envelope paracetamol in thematrix of CAP and shellac for masking the bitter taste of the drug. By using the shakeextracting method to assay the drug content in the matrix, the precision was found to be more than 95% and the