维拉帕米对大鼠胃溃疡的影响

THE EFFECT OF VERAPAMIL ON SEVERAL GASTRIC ULCER MODELS IN RATS

摘要: 钙拮抗剂主要用于治疗心血管疾病,对消化系统特别是消化性溃疡的作用研究较少,但最近有资料表明,钙拮抗剂可以抑制胃平滑肌收缩,抑制胃酸分泌。这些资料揭示钙可能在消化性溃疡的发病中起作用。为此,我们研究了维拉帕米对三种大鼠胃溃疡的作用。以呋喃唑酮为阳性对照,以期了解维拉帕米的作用特点并分析其机理。

Abstract: Verapamil at small dose (20mg/kg) was found to be an effective anti-ulcer agent in the stress-restraint ulcer and the acetic acid-induced chronic ulcer in rats. However, the drug was shown to be ineffective to the pyloric ligation-indueed ulcer and had no