盐酸普鲁卡因胺膜控片的研究
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摘要: 本文研究了盐酸普鲁卡因胺(PA·HCl)膜控片(B)的处方组成,制备工艺,体外溶出速率;利用HPLC法测定了体内PA及其活性代谢物N-乙酰普鲁卡因胺(NAPA)的血药浓度经时曲线;体内PA实验数据按双室模型用电子计算机进行处理得各药动学参数;B片剂体内外测定数据具有相关性。Abstract: This paper deals with the formulation, preparation of a membrane-controlled release tablet of procainamidc hydrochloride(B). The in vitro dissolution and in vivo pharmacokinetics of the tablet were also determined and compared. Experiments utilized a perm
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