瞬即达到稳态浓度的指数输注法

AN EXPONENTIAL INFUSION METHOD FOR THE RAPID ATTAINMENT AND MAINTENANCE OF A STEADY STATE PLASMA LEVEL

摘要: 本文提出一种指数输注法,通过首次给予负荷剂量,同时进行单指数输注,即可达到并维持在期望的稳态血药浓度。有关方程是根据双指数衰减动力学性质的线性乳突状模型,经卷积积分方法解得的。本文尚指出如何付诸实施。

Abstract: An exponential infusion method is presented, hoping that a desired steady state plasma drug concentration can be instantaneously achieved and maintained by the intravenous administration of an initial bolus loading dose in conjunction with an monocxponent