硝苯吡啶光稳定性快速测定法的探讨

A Rapid Assay of Photostability on Nifedipine and Its Tablets

摘要: 硝苯吡啶(nifedipine,NFP)主要起抑制钙离子运转作用,广泛用于治疗心绞痛。由于NFP的光稳定较差,本文采用光谱能量分布与自然光相近的镝灯光源,对NFP及其片剂进行了光加速实验,并且与自然光照射的样品对照,发现在这两种光照条件下的降解规律相同,为NFP的光稳定性建立了一种快速测定法。

Abstract: A fast photometrical measurement of nifedipine (NFP) exposed to Dysprosium halide lamp light (DRS) was developed. The concentration of NFP was determined by TLC; and the variation in color of its tablets was determined under DRS. The degradation product a