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假蜜环菌甲素合成方法的改进

Improved Synthesis of Armillarisin A

  • 摘要: 假蜜环菌甲素是从夜间发光的柳树朽木上生长的蜜环菌培养液中分离的荧光物质,化学结构为3-乙酰基-5-羟甲基-7-羟基-香豆素(Ⅵ)。该药兼有利胆、解痉、止痛、消炎等多种作用,可单独用于治疗非严重梗阻型急性胆道感染,其特点为起效快、活性高、剂量小(注射一次

     

    Abstract: Much improvement was made in the synthesis of Armillarisin A. Our first efforts were focussed on developing an alternative and efficient method for the preparation of the key intermediate, 5-hydroxymethyl-resorcinal by lithium aluminium hydride reduction

     

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