青霉素结合蛋白测定技术的研究
Detection of Penicillin-Binding Protein
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摘要: 当前,细菌耐药性问题日趋严重,给临床治疗带来困难,对β-内酰胺类抗生素而言,某些菌青霉素结合蛋白(PBPs)改变造成的耐药性,是β-内酰胺类抗生素的特点。一般细菌的PBPsAbstract: A method is described for detecting tritium-labelled penicillin-binding proteins (PBPs) of Streptococcus pneumoniae. The samples of PBPs were obtained using whole organisms treated with ~3H-benzyl-penicillin. Sodium lauryl sarcosinate (Sarkosyl) was fou
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